Altered T and B lymphocyte signaling pathways in lupus
Altered T and B lymphocyte signaling pathways in lupus
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DOI：
10.1016/j.autrev.2008.07.040
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发表时间：
2009-01-01
影响因子：
13.6
通讯作者：
Peng, Stanford L.
中科院分区：
文献类型：
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作者：
Peng, Stanford L.
系统性红斑狼疮（SLE）的特征是T和B淋巴细胞的信号通路失调，从观察到的细胞过度活跃和高反应性开始，到最近的研究集中在这种现象的遗传和分子基础上。本文综述了最近阐明的信号转导异常，目前认为是固有的T和/或B细胞在人类SLE。(c)2008 Elsevier B. V.保留所有权利。
Systemic lupus erythematosus (SLE) has long been recognized to be characterized by dysregulated signaling pathways in T and B lymphocytes, beginning with observations of cellular hyperactivity and hyperresponsiveness, and evolving to recent studies focused upon the genetic and molecular bases of such phenomena. This review focuses on recently elucidated signaling abnormalities currently thought to be intrinsic to T and/or B cells in human SLE. (c) 2008 Elsevier B.V. All rights reserved.