Femtoliter-scale optical nanofiber sensors.
Femtoliter-scale optical nanofiber sensors.
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DOI：
10.1364/oe.23.028408
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发表时间：
2015-11
期刊：
影响因子：
3.8
通讯作者：
Lei Zhang;Zhiyong Li;Jinxia Mu;W. Fang;L. Tong
中科院分区：
文献类型：
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作者：
Lei Zhang;Zhiyong Li;Jinxia Mu;W. Fang;L. Tong
我们报告了一个强大的和敏感的光学传感器与飞升规模的检测体积。该传感器是通过将直径为800 nm的探针嵌入微流控芯片中，探测光垂直于5 μ m宽的检测通道传播而制成的。为了验证传感器的有效性，我们提出了荧光强度和折射率（RI）的测量，检测限分别为1 × 10（-7）M的荧光素和2.8 × 10（-4）RIU。这里所示的飞秒级光学拉曼传感器可以提供一个紧凑和多功能的传感平台，用于超低量样品的灵敏和快速检测，以及研究单分子的动力学。
We report a robust and sensitive optical nanofiber sensor with a femtoliter-scale detection volume. The sensor is fabricated by embedding a 800-nm-diameter nanofiber into a microfluidic chip with probing light propagated perpendicular to a 5-μm-wide detection channel. To verify the effectiveness of the sensor, we present measurements of fluorescence intensity and refractive index (RI) with detection limits of 1 × 10(-7) M for fluorescein and 2.8 × 10(-4) RIU, respectively. The femtoliter-scale optical nanofiber sensor shown here may provide a compact and versatile sensing platform for sensitive and fast detection of ultra-low-volume samples, as well as studying the dynamics of single molecule.