Cue reactivity in cannabis-dependent adolescents.
Cue reactivity in cannabis-dependent adolescents.
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大麻依赖青少年的提示反应性。
DOI：
10.1037/a0021117
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Lukas,ScottE
中科院分区：
文献类型：
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作者：
Nickerson,LisaD;Ravichandran,Caitlin;Lundahl,LeslieH;Rodolico,John;Dunlap,Steven;Trksak,GeorgeH;Lukas,ScottE
作者通过渴望操纵测量了事件相关电位，以研究 13 名大麻依赖青少年（CD；14-17 岁）药物提示反应性的神经相关性。在处理中性物体后和处理 MJ 用具 (MJP) 后再次评估 P300 对大麻 (MJ) 图片 (MJ-P300) 和对照图片 (C-P300) 的反应。还测量了自我报告的药物渴望和心率。 MJ-P300 大于 C-P300 (p<. 001)，处理 MJP 后 MJ-P300 和渴望均显着增加 (分别为 p=. 002 和 p=. 003)，渴望程度与 MJ-P300 之间没有关联。处理 MJP 不会影响心率。结果表明，患有 CD 的青少年对 MJ 刺激的注意力偏差在接触大麻用具后会增加。一般来说，结果与成年重度慢性大麻吸烟者的报告一致，尽管存在一些差异需要进一步调查。
The authors measured event-related potentials with a craving manipulation to investigate the neural correlates of drug cue reactivity in 13 adolescents who are cannabis dependent (CD; ages 14–17). The P300 responses to marijuana (MJ) pictures (MJ-P300) and control pictures (C-P300) were assessed after handling neutral objects and again after handling MJ paraphernalia (MJP). Self-reported drug craving and heart rates also were measured. MJ-P300 were larger than C-P300 (p<. 001), and both the MJ-P300 and craving increased significantly after handling MJP (p=. 002 and p=. 003, respectively), with no association between the magnitude of craving and MJ-P300. Heart rates were not affected by handling MJP. The results showed that adolescents who are CD have an attentional bias to MJ stimuli that increases after handling marijuana paraphernalia. Generally, the results are consistent with what has been reported for adult heavy chronic cannabis smokers, although there were some differences that require further investigation.