Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways
Different levels of thyroid hormones between impaired fasting glucose and impaired glucose tolerance: free T3 affects the prevalence of impaired fasting glucose and impaired glucose tolerance in opposite ways
复制标题
空腹血糖受损和糖耐量受损之间的甲状腺激素水平不同：游离 T3 以相反的方式影响空腹血糖受损和糖耐量受损的患病率。
DOI：
10.1111/cen.12384
复制
发表时间：
2014-06-01
影响因子：
3.2
通讯作者：
Peng Yongde
中科院分区：
文献类型：
--
作者：
Su Jing;Ding Xiaoying;Peng Yongde
ContextThere is a association between thyroid disorders and diabetesmellitus. Objective调查不同葡萄糖代谢状态下的甲状腺激素水平，分析甲状腺激素水平与不同类型的糖尿病前期和代谢参数之间的关系，在一个大型的甲状腺功能正常的非糖尿病population.MethodsA中，共有3328例无糖尿病或甲状腺功能障碍的受试者被纳入本横断面研究。根据口服葡萄糖耐量试验结果将受试者分为4组[糖耐量正常（NGR）、空腹血糖受损（IFG）、糖耐量受损（IGT）和联合糖耐量异常（CGI）]。结果IFG组FT 3水平及FT 3/FT 4比值（FT 3/FT 4）高于IGT组，而FT 4水平低于IGT组。FT 3/FT 4与餐后血糖（PPG）呈负相关[标准化β（beta）=-0中心点087; PIFG和CGI随FT 3水平升高，而IGT患病率随FT 3水平降低（P趋势：
ContextThere is an association between thyroid disorders and diabetes mellitus.ObjectiveTo investigate thyroid hormone levels in different glucose metabolic statuses, analyse relationships between thyroid hormone levels and different categories of prediabetes and metabolic parameters within a large euthyroid nondiabetic population.MethodsA total of 3328 subjects without diabetes or thyroid dysfunction were included in this cross-sectional study. Subjects were divided in to four groups [normal glucose tolerance (NGR), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and combined glucose intolerance (CGI)] according to the results of oral glucose tolerance test. Participants were then divided into four groups according to the quartile of free T3 (FT3) in their blood.ResultsSubjects with IFG had higher levels of FT3 and ratio of FT3 to FT4 (FT3/FT4), but lower level of free T4 (FT4) than subjects with IGT. FT3/FT4 was negatively associated with postprandial plasma glucose (PPG) [standardized beta (beta)=-0 center dot 087; PIFG and CGI was increased with the level of FT3, while the prevalence of IGT was decreased with the level of FT3 (P for trend: