Age-related decline in peripheral vascular health predicts cognitive impairment
Age-related decline in peripheral vascular health predicts cognitive impairment
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DOI：
10.1007/s11357-019-00063-5
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发表时间：
2019-04-01
期刊：
影响因子：
5.6
通讯作者：
Yabluchanskiy, Andriy
中科院分区：
文献类型：
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作者：
Csipo, Tamas;Lipecz, Agnes;Yabluchanskiy, Andriy
临床前研究表明，广泛性内皮细胞功能障碍和微血管损伤是年龄相关性血管性认知障碍和痴呆（VCID）的潜在可逆原因。本研究旨在验证这样一种假设，即外周循环中测量的与年龄相关的大血管和微血管功能障碍的严重程度是老年人认知能力的独立预测因子。在这项研究中，我们将63名健康个体纳入年轻（65岁）组。我们使用主成分分析（PCA）构建了一个综合的外周血管健康指数（VHI），包括外周微血管反应性、动脉内皮功能和血管硬度，作为衰老诱导的广义血管功能障碍的标志。外周血大血管和微血管内皮功能评估采用血流介导扩张（FMD）和激光散斑对比成像试验。脉搏波形分析用于评估增强指数（AIx），这是衡量动脉硬度的一种指标。使用CANTAB认知测试面板测量认知功能，然后应用PCA为每个参与者生成认知障碍指数（CII）。老年受试者表现出明显的大血管内皮功能受损（FMD, 5.6 +/- 0.7% vs年轻人8.3 +/- 0.6%,p=0.0061），动脉僵硬度增加（AIx 29.3 +/- 1.8% vs年轻人4.5 +/- 2.6%,p=0.0061）
Preclinical studies demonstrate that generalized endothelial cell dysfunction and microvascular impairment are potentially reversible causes of age-related vascular cognitive impairment and dementia (VCID). The present study was designed to test the hypothesis that severity of age-related macro- and microvascular dysfunction measured in the peripheral circulation is an independent predictor of cognitive performance in older adults. In this study, we enrolled 63 healthy individuals into young (65years old) groups. We used principal component analysis (PCA) to construct a comprehensive peripheral vascular health index (VHI) encompassing peripheral microvascular reactivity, arterial endothelial function, and vascular stiffness, as a marker of aging-induced generalized vascular dysfunction. Peripheral macrovascular and microvascular endothelial function were assessed using flow-mediated dilation (FMD) and laser speckle contrast imaging tests. Pulse waveform analysis was used to evaluate the augmentation index (AIx), a measure of arterial stiffness. Cognitive function was measured using a panel of CANTAB cognitive tests, and PCA was then applied to generate a cognitive impairment index (CII) for each participant. Aged subjects exhibited significantly impaired macrovascular endothelial function (FMD, 5.6 +/- 0.7% vs. 8.3 +/- 0.6% in young, p=0.0061), increased arterial stiffness (AIx 29.3 +/- 1.8% vs 4.5 +/- 2.6% in young, p