Total Body PET: Why, How, What for?
Total Body PET: Why, How, What for?
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DOI：
10.1109/trpms.2020.2985403
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发表时间：
2020-05
影响因子：
4.4
通讯作者：
Karp JS
中科院分区：
文献类型：
--
作者：
Surti S;Pantel AR;Karp JS
PET仪器现在具有长轴向视场（LAFOV），可以同时成像全身，或至少是头部和躯干，而无需床平移。这有两个主要的好处，系统灵敏度的显著增加和测量动力学的能力与更广泛的轴向覆盖，以包括多个器官。这份手稿提出了一项技术的审查导致了这些新仪器的引入，并解释了拉法夫PET-CT仪器的好处。迄今为止，为TB-PET开发了两个平台，这是加州大学戴维斯分校（UC Davis）和宾夕法尼亚大学（Penn）的探索者联盟的成果。加州大学戴维斯分校的uEXPLORER的视距为194厘米，由United Imaging Healthcare开发。PennPET探索者是宾夕法尼亚大学开发的，基于飞利浦医疗保健公司的数字探测器。这种多环系统是可扩展的，已经测试了3个环，但现在正在扩展到140厘米的6个环。两种EXPLORER系统的初步人体研究已经证明了LAFOV扫描仪在临床和研究应用中的成功实施和好处。这种研究的例子在这份手稿中有描述。
PET instruments are now available with a long axial field-of-view (LAFOV) to enable imaging the total-body, or at least head and torso, simultaneously and without bed translation. This has two major benefits, a dramatic increase in system sensitivity and the ability to measure kinetics with wider axial coverage so as to include multiple organs. This manuscript presents a review of the technology leading up to the introduction of these new instruments, and explains the benefits of a LAFOV PET-CT instrument. To date there are two platforms developed for TB-PET, an outcome of the EXPLORER Consortium of the University of California at Davis (UC Davis) and the University of Pennsylvania (Penn). The uEXPLORER at UC Davis has an AFOV of 194 cm and was developed by United Imaging Healthcare. The PennPET EXPLORER was developed at Penn and is based on the digital detector from Philips Healthcare. This multi-ring system is scalable and has been tested with 3 rings but is now being expanded to 6 rings for 140 cm. Initial human studies with both EXPLORER systems have demonstrated the successful implementation and benefits of LAFOV scanners for both clinical and research applications. Examples of such studies are described in this manuscript.