Attenuation of acute lung inflammation and injury by whole body cooling in a rat heatstroke model.
Attenuation of acute lung inflammation and injury by whole body cooling in a rat heatstroke model.
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DOI：
10.1155/2009/768086
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发表时间：
2009
影响因子：
--
通讯作者：
Lin MT
中科院分区：
文献类型：
--
作者：
Yang HH;Chang CP;Cheng RT;Lin MT
全身降温是目前治疗中暑的首选方法，因为目前还没有合适的治疗药物。在这项研究中，我们评估了全身降温对中暑时可能发生的急性肺部炎症和损伤的几个指标的影响。将麻醉后的大鼠随机分为以下两组：(a)不治疗或(b)中暑后立即全身降温。与正常对照组相比，未经处理的中暑大鼠胸膜渗出液体积和多形核细胞数量、肺myloperoxidase活性和诱导型一氧化氮合酶表达、肺组织损伤评分、支气管肺泡促炎细胞因子和谷氨酸、PaCO2水平均较高。相比之下，中暑时平均动脉压、心率、PaO2、pH和血HCO3−值均显著降低。全身降温可显著减少中暑时发生的急性肺部炎症损伤和电解质失衡。综上所述，全身降温可改善热致急性肺炎症和损伤及电解质失衡。
Whole body cooling is the current therapy of choice for heatstroke because the therapeutic agents are not available. In this study, we assessed the effects of whole body cooling on several indices of acute lung inflammation and injury which might occur during heatstroke. Anesthetized rats were randomized into the following groups and given (a) no treatment or (b) whole body cooling immediately after onset of heatstroke. As compared with the normothermic controls, the untreated heatstroke rats had higher levels of pleural exudates volume and polymorphonuclear cell numbers, lung myloperoxidase activity and inducible nitric oxide synthase expression, histologic lung injury score, and bronchoalveolar proinflammatory cytokines and glutamate, and PaCO2. In contrast, the values of mean arterial pressure, heart rate, PaO2, pH, and blood HCO3− were all significantly lower during heatstroke. The acute lung inflammation and injury and electrolyte imbalance that occurred during heatstroke were significantly reduced by whole body cooling. In conclusion, we identified heat-induced acute lung inflammation and injury and electrolyte imbalance could be ameliorated by whole body cooling.
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DOI：
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发表时间：
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影响因子：
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作者：
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影响因子：
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DOI：
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发表时间：
1996-06-01
影响因子：
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