Expression Patterns of Sulfatase Genes in the Developing Mouse Embryo
Expression Patterns of Sulfatase Genes in the Developing Mouse Embryo
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DOI：
10.1002/dvdy.22294
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发表时间：
2010-06-01
影响因子：
2.5
通讯作者：
Vortkamp, Andrea
中科院分区：
文献类型：
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作者：
Ratzka, Andreas;Mundlos, Stefan;Vortkamp, Andrea
哺乳动物硫酸酯酶参与多种过程，如激素调节、溶酶体降解和多种信号通路的调节。硫酸酯酶基因家族在小鼠中由14个成员组成，在人类中由17个成员组成。至少有八个成员的突变与人类疾病有关，主要疾病表现在神经系统和骨骼。尽管它们具有生物学意义，但对它们在胚胎发育过程中的表达知之甚少，特别是最近发现的基因家族成员。通过原位杂交，我们比较了9种硫酸酯酶：ArsB，ArsG，ArsI，ArsJ，Gains，Gns，Ids，Sulf1和Sulf2在妊娠中期小鼠胚胎中的表达模式。感兴趣的是，几种硫酸酯酶的重叠表达域可以在发育中的中枢神经系统，眼睛，骨骼和内脏器官中检测到。此外，新的表达模式的ArsG在脉络丛，ArsI在肥大的软骨细胞和ArsJ在关节被确定。发展动力学239：1779 - 1788，2010年。(C)2010 Wiley-Liss，Inc.
Mammalian sulfatase enzymes participate in various processes, such as hormone regulation, lysosomal degradation and modulation of several signaling pathways. The sulfatase gene family consists of 14 members in mice and 17 in humans. Mutations of at least eight members are associated with human disorders, with main disease manifestations in the nervous system and skeleton. Despite their biological significance, little is known about their expression during embryonic development, especially for the more recently discovered gene family members. By in situ hybridization, we compared the expression patterns of nine sulfatases: ArsB, ArsG, ArsI, ArsJ, Gains, Gns, Ids, Sulf1, and Sulf2 in midgestation mouse embryos. Of interest, overlapping expression domains of several sulfatases could be detected in the developing central nervous system, eye, skeleton, and inner organs. Moreover, novel expression patterns for ArsG in choroid plexus, ArsI in hypertrophic chondrocytes and ArsJ in joints were identified. Developmental Dynamics 239:1779-1788, 2010. (C) 2010 Wiley-Liss, Inc.