Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors.
Dietary choline supplementation to dams during pregnancy and lactation mitigates the effects of in utero stress exposure on adult anxiety-related behaviors.
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在怀孕和哺乳期间向母鼠补充膳食胆碱可以减轻子宫内压力暴露对成年焦虑相关行为的影响。
DOI：
10.1016/j.bbr.2014.03.031
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发表时间：
2014
影响因子：
2.7
通讯作者：
Stevens,KarenE
中科院分区：
文献类型：
--
作者：
Schulz,KalynnM;Pearson,JenniferN;Gasparrini,MaryE;Brooks,KaylaF;Drake-Frazier,Chakeer;Zajkowski,MeganE;Kreisler,AlisonD;Adams,CatherineE;Leonard,Sherry;Stevens,KarenE
脑胆碱能功能障碍与抑郁、焦虑和精神分裂症等神经精神疾病有关。母亲的压力暴露与成年后代的这些疾病有关，但产前压力与脑胆碱能功能之间的关系在很大程度上尚未被探索。因此，本研究采用啮齿类动物模型，实施了一项干预措施，旨在缓冲产前应激对发育中的脑胆碱能系统的潜在影响。在妊娠期和哺乳期分别饲喂饲喂胆碱补充饲料和对照饲料的对照母鼠和应激母鼠，通过开阔场、高零迷宫和社会互动测试评估成年子代的焦虑相关行为。在野外试验中，补充胆碱显著增加了应激和非应激雌性后代的中心调查，这表明补充胆碱可以减少雌性焦虑相关行为，而与产前应激暴露无关。在高零迷宫中，产前压力增加了喂食控制饮食（正常胆碱水平）的雌性后代的焦虑相关行为。然而，在妊娠期和哺乳期补充胆碱的雌性后代中，产前应激并没有增加焦虑相关行为，这表明饮食中补充胆碱可以改善产前应激对焦虑相关行为的影响。对于雄性大鼠来说，产前压力和饮食都不会影响它们在空旷地和高零迷宫中的焦虑相关行为。相比之下，围产期补充胆碱可以减轻男性产前压力引起的社会行为缺陷，而产前压力和补充胆碱都不会影响女性的社会行为。综上所述，这些数据表明围产期补充胆碱可以改善产前应激的性别特异性影响。
Brain cholinergic dysfunction is associated with neuropsychiatric illnesses such as depression, anxiety, and schizophrenia. Maternal stress exposure is associated with these same illnesses in adult offspring, yet the relationship between prenatal stress and brain cholinergic function is largely unexplored. Thus, using a rodent model, the current study implemented an intervention aimed at buffering the potential effects of prenatal stress on the developing brain cholinergic system. Specifically, control and stressed dams were fed choline-supplemented or control chow during pregnancy and lactation, and the anxiety-related behaviors of adult offspring were assessed in the open field, elevated zero maze and social interaction tests. In the open field test, choline supplementation significantly increased center investigation in both stressed and nonstressed female offspring, suggesting that choline-supplementation decreases female anxiety-related behavior irrespective of prenatal stress exposure. In the elevated zero maze, prenatal stress increased anxiety-related behaviors of female offspring fed a control diet (normal choline levels). However, prenatal stress failed to increase anxiety-related behaviors in female offspring receiving supplemental choline during gestation and lactation, suggesting that dietary choline supplementation ameliorated the effects of prenatal stress on anxiety-related behaviors. For male rats, neither prenatal stress nor diet impacted anxiety-related behaviors in the open field or elevated zero maze. In contrast, perinatal choline supplementation mitigated prenatal stress-induced social behavioral deficits in males, whereas neither prenatal stress nor choline supplementation influenced female social behaviors. Taken together, these data suggest that perinatal choline supplementation ameliorates the sex-specific effects of prenatal stress.