Kazusa mammalian cDNA resources: towards functional characterization of KIAA gene products
Kazusa mammalian cDNA resources: towards functional characterization of KIAA gene products
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DOI：
10.1093/bfgp/ell005
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发表时间：
2006-03-01
期刊：
影响因子：
--
通讯作者：
Ohara, Osamu
中科院分区：
文献类型：
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作者：
Nagase, Takahiro;Koga, Hisashi;Ohara, Osamu
Kazusa cDNA项目开创了一项广泛的完整人类cDNA测序计划，并专注于测序工作，特别是编码大蛋白的大cDNA。超过2000个人类基因，被称为‘KIAA’基因，通过这个cdna项目被初步鉴定。由于许多KIAA基因的功能仍未确定，我们目前的重点是确定它们在体内的生物学功能。本文综述了KIAA基因的研究现状，并展望了KIAA基因功能研究的发展方向。
The Kazusa cDNA project pioneered an extensive sequencing project of human cDNAs in their entirety and focused sequencing efforts particularly on large cDNAs encoding large proteins. More than 2000 human genes, referred to as 'KIAA' genes, were initially identified through this cDNA project. Since many KIAA genes still remain functionally uncharacterized, our current focus is to determine their biological functions in vivo. In this review, we describe the current status of the Kazusa mammalian cDNA resources and the future direction of the functional characterization of KIAA genes.