MORPHOLOGICAL AND HISTOLOGICAL STUDY OF CASTRATION-INDUCED DEGENERATION AND ANDROGEN-INDUCED REGENERATION IN THE MOUSE PROSTATE
MORPHOLOGICAL AND HISTOLOGICAL STUDY OF CASTRATION-INDUCED DEGENERATION AND ANDROGEN-INDUCED REGENERATION IN THE MOUSE PROSTATE
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DOI：
10.1095/biolreprod34.5.973
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发表时间：
1986-06-01
影响因子：
3.6
通讯作者：
DONJACOUR, AA
中科院分区：
文献类型：
--
作者：
SUGIMURA, Y;CUNHA, GR;DONJACOUR, AA
成年小鼠腹侧和背外侧前列腺（VP和DLP）的导管结构的退行性和再生性变化进行了研究，在显微解剖标本超过14天的时间过程中阉割后，随后在14天的丙酸睾酮给药。去势后，前列腺两叶远端（通常在包膜附近）约有35%的导管尖端和分支点丢失。相比之下，在前列腺的更近端区域（更靠近尿道），导管在萎缩状态下存活。去势雄性大鼠给予丙酸睾丸酮后，远端区域的导管形态完全再生。在VP中，雄激素替代只是使腺体恢复到其先前的大小，伴有中度导管扩张;在DLP中，丙酸睾酮治疗14天后，在导管远端区域引起过度上皮内折和导管扩张。这些结果表明，雄激素的反应性和依赖性是不同的远端与近端导管。远端导管是雄激素依赖性和雄激素敏感性的;在近端区域，雄激素依赖性不那么严格。
Degenerative and regenerative changes in the ductal architecture of the ventral and dorsolateral prostates (VP and DLP) of the adult mouse were investigated in microdissected specimens over a time-course of 14 days following castration and subsequently during 14 days of administration of testosterone propionate. After castration, about 35% of the ductal tips and branch-points were lost in distal regions (usually near the capsule) in both prostatic lobes. By contrast, in more proximal regions of the prostate (closer to the urethra), the ducts survived in an atrophic condition. The ductal morphology that bad been lost in the distal regions completely regenerated after testosterone propionate was administered to the castrated males. In the VP, androgen replacement simply returned the gland to its former size with moderate ductal distension; in the DLP, excessive epithelial infoldings and ductal distension were elicited in the distal regions of the ducts after 14 days of treatment with testosterone propionate. These results sugges that androgenic responsiveness and dependency are different in distal versus proximal ducts. Distal ducts are exquisitely androgen-dependent and androgen-sensitive; in proximal regions, androgen-dependency is not as strict.