Teaching structural Bioinformatics at the undergraduate level
Teaching structural Bioinformatics at the undergraduate level
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DOI：
10.1002/bmb.2003.494031060287
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发表时间：
2003-11-01
影响因子：
1.4
通讯作者：
Oliva, B
中科院分区：
文献类型：
--
作者：
Centeno, NB;Villà-Freixa, J;Oliva, B
了解结构生物学的基本原理正在成为大多数生物学本科课程的主要研究课题。在基因组和蛋白质组时代，生物学学生必须掌握与蛋白质序列和结构相关的概念，以培养可能在广泛应用中有用的技能。在此背景下，本文展示了一种基于计算机实践方法的结构生物学教学方案，包括计算基因组学和结构生物信息学工具。学生学习使用大多数领先的计算机程序来完成从序列到结构到最终功能的完整路径。在课程中，他们被教导根据序列和结构信息构建蛋白质模型。学生还获得了关于自动程序的批判性观点，并学会辨别最终模型的可能结构和不可能结构。
Understanding the basic principles of structural biology is becoming a major subject of study in most undergraduate level programs in biology. In the genomic and proteomic age, it is becoming indispensable for biology students to master concepts related to the sequence and structure of proteins in order to develop skills that may be useful in a wide range of applications. Within this context, this article shows a scheme for teaching structural biology based on hands-on computer approaches, including computational genomics, and structural bioinformatics tools. The students learn to use most of the leading computer programs available for the complete path that goes from sequence to structure and eventually function. During the course, they are taught to build models of proteins based on sequence and structure information. The students are also provided with a critical point of view on automatic procedures and learn to discern between likely and unlikely structures of their final models.