Effects of prenatal cocaine and heroin exposure on neuronal dendrite morphogenesis and spatial recognition memory in mice
Effects of prenatal cocaine and heroin exposure on neuronal dendrite morphogenesis and spatial recognition memory in mice
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产前可卡因和海洛因暴露对小鼠神经元树突形态发生和空间识别记忆的影响
DOI：
10.1016/j.neulet.2012.06.023
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发表时间：
2012-08-01
影响因子：
2.5
通讯作者：
Ma, Lan
中科院分区：
文献类型：
--
作者：
Lu, Ruhui;Liu, Xing;Ma, Lan
可卡因和海洛因是育龄妇女滥用者经常使用的精神活性物质。在本研究中，我们利用宫内电穿孔标记技术和新奇识别模型来评估出生前暴露于可卡因或海洛因对小鼠皮质神经元形态发育和出生后认知功能的影响。结果表明，孕期可卡因暴露增加了大鼠躯体感觉皮层锥体神经元树突的生长，而海洛因暴露则降低了锥体神经元的树突长度和分支数目。此外，尽管没有观察到产前接触可卡因或海洛因对新物体识别的影响，但产前接触可卡因的后代对放置在新位置的物体没有表现出探索偏好，产前接触海洛因的小鼠对新位置物体的探索倾向降低。这些数据表明，母亲在怀孕期间服用可卡因或海洛因会导致躯体感觉皮质锥体神经元的形态变化，并表明产前服用成瘾物质可能会损害成年后代的短期空间记忆。(C)2012爱思唯尔爱尔兰有限公司。保留所有权利。
Cocaine and heroin are psychoactive substances frequently used by woman abusers of childbearing age. In this study, we used in utero electroporation labeling technique and novelty recognition models to evaluate the effects of prenatal exposure of mice to cocaine or heroin on the morphological development of cortical neurons and postnatal cognitive functions. Our results showed that prenatal cocaine exposure increased dendrite outgrowth, and prenatal heroin exposure decreased dendrite length and branch number in pyramidal neurons in the somatosensory cortex. Furthermore, although no effects of prenatal cocaine or heroin exposure on novel object recognition were observed, offspring prenatally exposed to cocaine exhibited no exploration preference for objects placed in novel locations, and mice prenatally exposed to heroin showed a reduced tendency of exploration for objects in novel locations. These data demonstrate that maternal cocaine or heroin administration during pregnancy causes morphological alterations in pyramidal neurons in the somatosensory cortex and suggest that prenatal administration of addictive substances may impair short-term spatial memory in adult offspring. (C) 2012 Elsevier Ireland Ltd. All rights reserved.