The apolipoprotein E ε4 allele and incident Alzheimer's disease in persons with mild cognitive impairment
The apolipoprotein E ε4 allele and incident Alzheimer's disease in persons with mild cognitive impairment
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DOI：
10.1080/13554790490903038
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发表时间：
2005-02-01
期刊：
影响因子：
0.8
通讯作者：
Bennett, DA
中科院分区：
文献类型：
--
作者：
Aggarwal, NT;Wilson, RS;Bennett, DA
拥有一个或多个拷贝的载脂蛋白E（APOE）ε 4等位基因是阿尔茨海默病（AD）的已知危险因素，但ε 4等位基因是否与轻度认知障碍（MCI）患者的发病率相关尚不确定。我们用宗教秩序研究的数据解决了这个问题。参与者是181名年龄较大的天主教神职人员，他们符合基于统一结构化临床评估的MCI标准; 56人（30.9%）至少有一个ε 4等位基因。每年重复进行临床评估，包括痴呆和AD的临床分类。在平均5.7年的观察期间，79人（43.6%）发展为AD。在控制年龄、性别和教育的比例风险模型中，拥有ε 4等位基因与阿尔茨海默病风险增加93%相关（95%CI：1.02，2.63）。与年轻参与者相比，老年参与者中ε 4的影响略有显着降低（p= 0.053）。结果表明，拥有ε 4等位基因确实会增加MCI患者患AD的风险。
Possession of one or more copies of the apolipoprotein E (APOE) epsilon4 allele is a known risk factor for Alzheimer's disease (AD), but it is uncertain whether the epsilon4 allele is associated with disease incidence among persons with mild cognitive impairment (MCI). We addressed this issue with data from the Religious Orders Study. Participants were 181 older Catholic clergy members who met criteria for MCI based on a uniform structured clinical evaluation; 56 (30.9%) had at least one epsilon4 allele. Clinical evaluations, which included clinical classification of dementia and AD, were repeated annually. During a mean of 5.7 years of observation, 79 persons (43.6%) developed AD. In a proportional hazards model that controlled for age, sex, and education, possession of an epsilon4 allele was associated with a 93% increase in the risk of developing Alzheimer's disease (95% CI: 1.02, 2.63). There was a marginally significant reduction in the effect of epsilon4 in older compared to younger participants (p=.053). The results suggest that possession of an epsilon4 allele does increase risk of AD in persons with MCI.