The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway
The FHA domain, a phosphoamino acid binding domain involved in the DNA damage response pathway
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DOI：
10.1101/sqb.2000.65.413
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发表时间：
2000-01-01
期刊：
影响因子：
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通讯作者：
Elledge, SJ
中科院分区：
文献类型：
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作者：
Huang, M;Elledge, SJ
到目前为止，已经鉴定了约160种含FHA的蛋白质（参见http：//smart. org/2014/10/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/2014/20恩布尔-海德堡。de）。虽然这些蛋白质中的大多数似乎具有核功能，但其中一些蛋白质定位于细胞核以外的细胞隔室中。例如，拟南芥激酶相关蛋白磷酸酶（KAPP）是一种与受体样蛋白激酶结合的细胞质蛋白（Stone et al.1994）。另一种含细胞质FHA的蛋白质是驱动蛋白样马达蛋白KIF 1B，其与线粒体共定位并可在体外沿着微管转运线粒体（Nangaku et al. 1994）。
About 160 FHA-containing proteins have been identified so far (see http://smart. embl-heidelberg. de). While the majority of these proteins appear to have nuclear functions, a few of them are localized in cellular compartments other than the nucleus. For example, the Arabidopsis kinase-associated protein phosphatase (KAPP) is a cytoplasmic protein that binds to the receptor-like protein kinase (Stone et al. 1994). One other cytoplasmic FHA-containing protein is the kinesin-like motor protein KIF1B, which colocalizes with mitochondria and can transport mitochondria along microtubules in vitro (Nangaku et al. 1994).