Functional Specialization of Medial Auditory Belt Cortex in the Alert Rhesus Monkey
Functional Specialization of Medial Auditory Belt Cortex in the Alert Rhesus Monkey
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DOI：
10.1152/jn.00167.2009
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发表时间：
2009-09-01
影响因子：
2.5
通讯作者：
Rauschecker, Josef P.
中科院分区：
文献类型：
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作者：
Kusmierek, Pawel;Rauschecker, Josef P.
Kusmierek P, Rauschecker JP。警觉性恒河猴内侧听觉带皮层的功能特化。中国生物医学工程学报（英文版）32(2):444 - 444。首次发表于2009年7月1日；doi: 10.1152 / jn.00167.2009。用两只警觉的恒河猴的微电极记录的音调、噪音爆发、猴子叫声（MC）和环境声音（ES）测试了内侧听觉带两个区域（中间内侧区[MM]和吻侧内侧区[RM]）神经单元的反应。为了比较，我们还对听觉皮层的两个核心区域（初级听觉区[A1]和吻侧区域[R]）进行了录音。4个场均显示耳蜗组织，A1和MM的最佳（中心）频率[BF(c)]梯度方向与R和RM相反。中间带的特点是对带通噪声的偏好强于对核心区中间的纯音的偏好。相对于R和RM两个吻侧区域，MM和A1两个较后（中间）区域的反应潜伏期更短，在MM和A1中，高BF(c)的反应潜伏期低至6 ms，并且强烈依赖BF(c)。与核心区相比，内侧带区对所有刺激，特别是对噪声爆发的选择性更高。对音调和噪声爆发的选择性增加也发现在前野；对于高度时间调制的ES，情况正好相反。神经反应的结构分析表明，神经元在所有领域都是由低水平的声学特征驱动的。因此内侧带区域RM和MM必须被认为是听觉皮层加工的早期阶段。时间加工指标的前后差异表明，R和RM可能与A1和MM属于不同的层次或不同的计算网络。
Kusmierek P, Rauschecker JP. Functional specialization of medial auditory belt cortex in the alert rhesus monkey. J Neurophysiol 102: 1606-1622, 2009. First published July 1, 2009; doi:10.1152/jn.00167.2009. Responses of neural units in two areas of the medial auditory belt (middle medial area [MM] and rostral medial area [RM]) were tested with tones, noise bursts, monkey calls (MC), and environmental sounds (ES) in microelectrode recordings from two alert rhesus monkeys. For comparison, recordings were also performed from two core areas (primary auditory area [A1] and rostral area [R]) of the auditory cortex. All four fields showed cochleotopic organization, with best (center) frequency [BF(c)] gradients running in opposite directions in A1 and MM than in R and RM. The medial belt was characterized by a stronger preference for band-pass noise than for pure tones found medially to the core areas. Response latencies were shorter for the two more posterior (middle) areas MM and A1 than for the two rostral areas R and RM, reaching values as low as 6 ms for high BF(c) in MM and A1, and strongly depended on BF(c). The medial belt areas exhibited a higher selectivity to all stimuli, in particular to noise bursts, than the core areas. An increased selectivity to tones and noise bursts was also found in the anterior fields; the opposite was true for highly temporally modulated ES. Analysis of the structure of neural responses revealed that neurons were driven by low-level acoustic features in all fields. Thus medial belt areas RM and MM have to be considered early stages of auditory cortical processing. The anteroposterior difference in temporal processing indices suggests that R and RM may belong to a different hierarchical level or a different computational network than A1 and MM.