Articular cartilage tissue engineering: the role of signaling molecules.
Articular cartilage tissue engineering: the role of signaling molecules.
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DOI：
10.1007/s00018-015-2115-8
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Athanasiou K
中科院分区：
文献类型：
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作者：
Kwon H;Paschos NK;Hu JC;Athanasiou K
骨关节炎的有效早期疾病改善选择仍然缺乏。组织工程方法在体外产生软骨已成为关节软骨修复和再生的一个有前途的选择。来源于软骨发育和稳态知识的信号分子和基质修饰剂已被用作软骨组织工程的生化刺激物，并导致工程化软骨功能的改善。新软骨的临床转化面临挑战，例如工程化软骨的表型不稳定性、整合不良、炎症和关节炎环境中的分解代谢因素;这些都可能导致植入的新软骨失败。全面了解参与骨关节炎发病机制的信号分子及其对工程软骨的作用将是至关重要的。因此，虽然继续从软骨发育和体内平衡中获得灵感很重要，但将骨关节炎发病机制的知识纳入软骨组织工程变得越来越必要。
Effective early disease modifying options for osteoarthritis remain lacking. Tissue engineering approach to generate cartilage in vitro has emerged as a promising option for articular cartilage repair and regeneration. Signaling molecules and matrix modifying agents, derived from knowledge of cartilage development and homeostasis, have been used as biochemical stimuli toward cartilage tissue engineering and have led to improvements in the functionality of engineered cartilage. Clinical translation of neocartilage faces challenges, such as phenotypic instability of the engineered cartilage, poor integration, inflammation, and catabolic factors in the arthritic environment; these can all contribute to failure of implanted neocartilage. A comprehensive understanding of signaling molecules involved in osteoarthritis pathogenesis and their actions on engineered cartilage will be crucial. Thus, while it is important to continue deriving inspiration from cartilage development and homeostasis, it has become increasing necessary to incorporate knowledge from osteoarthritis pathogenesis into cartilage tissue engineering.