A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021.
A Bibliometric Analysis of Exosomes in Cardiovascular Diseases From 2001 to 2021.
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DOI：
10.3389/fcvm.2021.734514
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发表时间：
2021
影响因子：
3.6
通讯作者：
Xu H
中科院分区：
文献类型：
--
作者：
Ma D;Guan B;Song L;Liu Q;Fan Y;Zhao L;Wang T;Zhang Z;Gao Z;Li S;Xu H
背景：外泌体在心血管疾病（CVD）中的研究已成为一个具有重要价值和潜力的研究领域。然而，在这一领域的文献计量学研究很少。通过文献计量学分析，了解外来体在心血管疾病中的研究热点和发展趋势，为今后的基础和临床研究提供参考。研究方法：从Web of Science Core Collection中挑选出关于CVD中外来体的文章和评论，并使用CiteSpace和VOSviewer软件生成知识图谱。结果：共纳入1,039篇文献。CVD中外来体的数量逐年增加。这些出版物来自60个国家/地区，以美国和中国为首。主要研究机构为上海交通大学和南京医科大学。《循环研究》是研究最多的期刊和共同被引期刊。我们确定了473位作者，其中Lucio Barile的文章数量最多，Thery C最常被共同引用。经过分析，最常见的关键词是心肌梗死、microRNA和间充质干细胞。缺血性心脏病，发病机制，再生，干细胞，靶向治疗，生物标志物，心脏保护等是当前和发展中的研究领域。结论：通过文献计量学和可视化方法，明确了外来体在心血管疾病中的研究热点和发展趋势。外泌体的研究在心血管医学中正蓬勃发展。再生医学、外泌体工程、运载工具和生物标志物可能会成为未来研究的重点。
Background: Exosomes in cardiovascular diseases (CVDs) have become an active research field with substantial value and potential. Nevertheless, there are few bibliometric studies in this field. We aimed to visualize the research hotspots and trends of exosomes in CVDs using a bibliometric analysis to help understand the future development of basic and clinical research. Methods: The articles and reviews regarding exosomes in the CVDs were culled from the Web of Science Core Collection, and knowledge maps were generated using CiteSpace and VOSviewer software. Results: A total of 1,039 articles were included. The number of exosome articles in the CVDs increased yearly. These publications came from 60 countries/regions, led by the US and China. The primary research institutions were Shanghai Jiao Tong University and Nanjing Medical University. Circulation Research was the journal and co-cited journal with the most studies. We identified 473 authors among which Lucio Barile had the most significant number of articles and Thery C was co-cited most often. After analysis, the most common keywords are myocardium infarction, microRNA and mesenchymal stem cells. Ischemic heart disease, pathogenesis, regeneration, stem cells, targeted therapy, biomarkers, cardiac protection, and others are current and developing areas of study. Conclusion: We identified the research hotspots and trends of exosomes in CVDs using bibliometric and visual methods. Research on exosomes is flourishing in the cardiovascular medicine. Regenerative medicine, exosome engineering, delivery vehicles, and biomarkers will likely become the focus of future research.