A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture
A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture
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DOI：
10.1152/ajpheart.00036.2012
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发表时间：
2012-09-01
影响因子：
4.8
通讯作者：
Weinbaum, Sheldon
中科院分区：
文献类型：
--
作者：
Maldonado, Natalia;Kelly-Arnold, Adreanne;Weinbaum, Sheldon
Maldonado N, Kelly-Arnold A, Vengrenyuk Y, lauder D, Fallon JT, Virmani R, Cardoso L, Weinbaum S. A动脉粥样硬化斑块稳定性的机制分析：斑块破裂的潜在意义。[J] .中国生物医学工程学报，2016,31(2):444 - 444。2012年7月9日首次发表；doi: 10.1152 / ajpheart.00036.2012。微钙化（mu Calcs）在易损斑块破裂的生物力学中的作用。我们的实验室先前提出（参考文献44），使用非常有限的组织样本，在纤维帽中适当嵌入钙可以显着增加帽的不稳定性。这项研究得到了极大的扩展。使用6.7 μ m分辨率的高分辨率显微计算机断层扫描和非钙化组织学检查了92例包含62个纤维动脉粥样瘤的人冠状动脉，并特别强调钙化颗粒
Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, Virmani R, Cardoso L, Weinbaum S. A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. Am J Physiol Heart Circ Physiol 303: H619-H628, 2012. First published July 9, 2012; doi:10.1152/ajpheart.00036.2012.-The role of microcalcifications (mu Calcs) in the biomechanics of vulnerable plaque rupture is examined. Our laboratory previously proposed (Ref. 44), using a very limited tissue sample, that mu Calcs embedded in the fibrous cap proper could significantly increase cap instability. This study has been greatly expanded. Ninety-two human coronary arteries containing 62 fibroatheroma were examined using high-resolution microcomputed tomography at 6.7-mu m resolution and undecalcified histology with special emphasis on calcified particles