RANK ligand and the regulation of skeletal remodeling
RANK ligand and the regulation of skeletal remodeling
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DOI：
10.1172/jci200318358
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发表时间：
2003-04-01
影响因子：
15.9
通讯作者：
Bell, NH
中科院分区：
文献类型：
--
作者：
Bell, NH
结论那么我们今天的立场是什么？我们现在认识到，CX3CR1 和 fractalkine 可能是动脉粥样硬化形成的重要参与者，并且 CX3CR1 含有调节其粘附和信号传导功能的多态性，并与降低动脉粥样硬化性心血管疾病的风险相关。但要真正了解CX3CR1和其他基因在动脉粥样硬化等高度复杂的慢性疾病过程中的机制，实验模型和临床研究都需要新的实用中间标记。
ConclusionSo where do we stand today? We now appreciate that CX3CR1 and presumably fractalkine are important players in atherogenesis, and that CX3CR1 contains polymorphisms that modulate its adhesive and signaling functions and are associated with reduced risk of atherosclerotic cardiovascular disease. But to truly understand the mechanism of CX3CR1 and other genes in a highly complex and chronic disease process such as atherosclerosis, new practical intermediate markers are required in both experimental models and clinical studies.