Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'.
Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'.
复制标题
家族性恶性黑色素瘤起源于可遗传的黑色素细胞病变。
作者：
W. Clark;R. Reimer;M. Greene;A. Ainsworth;M. Mastrangelo
在来自六个黑色素瘤家族的37名患者中描述了独特的黑色素细胞痣。在作者检查的家庭成员中，17名黑色素瘤患者中有15名患者和41名非黑色素瘤亲属中的22名患者有独特的葡萄胎。这些葡萄胎的临床和组织学特征被命名为“B-K葡萄胎综合征”。该综合征的临床特征包括上躯干和四肢突出的葡萄胎小于10个到大于100个，葡萄胎大小(5 mm到15 mm)、轮廓和颜色组合不同。组织学上，B-K葡萄胎表现为不典型的黑素细胞增生、淋巴细胞渗入、细小的纤维组织增生和复合性痣或新生血管内的新生血管。照片记录了两个B-K葡萄胎转变为恶性黑色素瘤的过程。
Distinctive melanocytic moles are described in 37 patients from six melanoma families. Among the family members examined by the authors, 15 of 17 patients with melanoma and 22 of 41 nonmelanoma relatives had the unique moles. The clinical and histological features of these moles have been designated the "B-K mole syndrome." The clinical features of the syndrome include the presence of less than 10 to greater than 100 moles prominent of the upper trunk and extremities, and variability of mole size (5 mm to 15 mm), outline, and color combination. Histologically, B-K moles show atypical melanocytic hyperplasia, lymphocytic infiltration, delicate fibroplasia, and new blood vessels that occur within a compound nevus or de novo. The transformation of two B-K moles into malignant melanomas was documented photographically.