The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease
The role of enhanced depth imaging optical coherence tomography in chronic Vogt-Koyanagi-Harada disease
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DOI：
10.1136/bjophthalmol-2015-308091
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发表时间：
2017-02-01
影响因子：
4.1
通讯作者：
Chee, Soon-Phaik
中科院分区：
文献类型：
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作者：
Jap, Aliza;Chee, Soon-Phaik
目的确定增强深度成像光学相干断层扫描（EDI-OCT）在慢性Vogt-Koyanagi-Harada（VKH）disease.Methods所有连续患者的记录与VKH看到在新加坡国家眼科中心进行了回顾性审查，同时EDI-OCT和吲哚菁绿色血管造影（ICGAs）获得6个月或更长时间后发病，人口统计学和疾病持续时间。结果共纳入52例患者的105对EDI-OCT和ICGA图像。平均年龄为51.7岁。半数患者（26例）为男性，大多数为中国人（39例患者，75.0%）。平均病程为106.3个月。有79次ICGA活动发作。当ICGA安静时（平均值=187.31 mu），平均SFCT比ICGA活跃时（平均值=272.38 mu，p=0.002）更薄。SFCT与ICGA评分呈正相关，与年龄、病程呈负相关。多因素分析显示，年龄、病程和ICGA是影响SFCT的主要因素。结论SFCT测量值与ICGA评分呈正相关，提示在慢性VKH患者中，SFCT可用于ICGA以外的疾病活动性监测，可能减少ICGA的使用次数。
Aims To determine the role of enhanced depth imaging optical coherence tomography (EDI-OCT) in chronic Vogt-Koyanagi-Harada (VKH) disease.Methods Records of all consecutive patients with VKH seen at the Singapore National Eye Centre were retrospectively reviewed for concurrent EDI-OCT and indocyanine green angiograms (ICGAs) obtained six or more months after disease onset, demographics and duration of disease. The ICGAs were scored based on the following signs: early choroidal stromal vessel hyperfluorescence and leakage, hypofluorescent dark dots, fuzzy vascular pattern of large stromal vessels and disc hyperfluorescence, and correlated with the subfoveal choroidal thickness (SFCT) measured using EDI-OCT. Only images of one eye were analysed.Results 105 pairs of EDI-OCT and ICGA of 52 patients were included. Mean age was 51.7 years. Half of the patients (26) were male and the majority were Chinese (39 patients, 75.0%). Mean duration of disease was 106.3 months. There were 79 ICGA active episodes. Mean SFCT was thinner when ICGA was quiet (mean=187.31 mu), than when the ICGA was active (mean=272.38 mu, p=0.002). There was a positive correlation of the SFCT with the ICGA score but a negative correlation with age and duration of disease. Multivariate analysis showed that age, duration of disease and ICGA were the main factors affecting SFCT.Conclusions The positive correlation of SFCT measurements with ICGA score suggests that it may be used to monitor disease activity in chronic VKH in addition to ICGA, possibly reducing the number of ICGAs required.