Cognitive impairment, retention and abstinence among cocaine abusers in cognitive-behavioral treatment
Cognitive impairment, retention and abstinence among cocaine abusers in cognitive-behavioral treatment
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DOI：
10.1016/s0376-8716(03)00092-9
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发表时间：
2003-08-20
影响因子：
4.2
通讯作者：
Hasin, D
中科院分区：
文献类型：
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作者：
Aharonovich, E;Nunes, E;Hasin, D
认知行为疗法（CBT）依赖于患者足够的认知功能，但长期使用可卡因可能会损害认知功能。因此，认知障碍可能会阻碍可卡因滥用者从CBT中获益的能力。为了开始解决这个问题，我们研究了认知障碍与两种治疗结果（治疗完成和戒断）之间的关系。在一项精神药理学临床试验中，对18名经过仔细筛选的无抑郁的可卡因依赖患者使用MicroCog计算机化测试组合来评估治疗开始时的认知表现。使用t检验来比较完成治疗者（在治疗中至少持续12周的患者）和中途退出者之间的认知功能。结果表明，完成治疗者在基线时表现出的认知表现明显优于中途退出治疗的患者。在完成治疗者和中途退出者之间有显著差异的认知领域是注意力、心理推理和空间处理。这项研究提供了初步证据，表明认知障碍可能会降低可卡因依赖的CBT治疗中的治疗保持率和戒断率。（C）2003爱思唯尔科学爱尔兰有限公司。保留所有权利。
Cognitive-behavioral therapy (CBT) depends on adequate cognitive functioning in patients, but prolonged cocaine use may impair cognitive functioning. Therefore, cognitive impairment may impede the ability of cocaine abusers to benefit from CBT. To begin to address this issue, we investigated the relationship between cognitive impairment and two treatment outcomes, therapy completion and abstention. Eighteen carefully screened non-depressed cocaine-dependent patients in a psychopharmacological clinical trial were administered the MicroCog computerized battery to assess cognitive performance at treatment entry. T-tests were used to compare cognitive functioning between completers (patients remaining in treatment at least 12 weeks) and dropouts. The results indicated that treatment completers had demonstrated significantly better cognitive performance at baseline than patients who dropped out of treatment. Cognitive domains that significantly distinguished between treatment completers and dropouts were attention, mental reasoning and spatial processing. This study provides preliminary evidence that cognitive impairments may decrease treatment retention and abstinence in CBT of cocaine dependence. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.