Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
Geographic isolates of atypical Parkinsonism and tauopathy in the tropics: Possible synergy of neurotoxins
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DOI：
10.1002/mds.21024
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发表时间：
2006-01-01
影响因子：
8.6
通讯作者：
Ohta, Shigeru
中科院分区：
文献类型：
--
作者：
Caparros-Lefebvre, Dominique;Steele, John;Ohta, Shigeru
在过去的60年中，在5个不同的地理分离株中报告了非典型帕金森综合征的异常高患病率。最早在关岛发现，后来在新几内亚、基伊半岛、瓜德罗普和新喀里多尼亚发现。我们研究了其中三个病灶的非典型帕金森综合征的表型，并观察到大多数与痴呆和肌萎缩侧索硬化的一些相似之处。这种疾病在关岛和新几内亚这两个地方的消失表明了一种在疾病消失之前尚未澄清的环境起源。在这些地方中的四个地方已经记录了番荔枝内酯和/或鱼藤酮的暴露，动物实验研究证明番荔枝内酯神经毒性，这与鱼藤酮神经毒性相似。同时暴露于乙酸配基和鱼藤酮对神经元产生协同毒性。(C)2006年，《社会运动》创刊。
Over the last 60 years an abnormally high prevalence of atypical Parkinsonism has been reported in 5 different geographic isolates. It was first described on Guam, later in New Guinea and in the Kii peninsula, on Guadeloupe, and in New Caledonia. We investigated the phenotype of atypical Parkinsonism in three of these foci and observed several similarities with dementia in most and amyotrophic lateral sclerosis in some. This disappearance of this disease in two places-Guam and New Guinea-suggested an environmental origin which has not been clarified before the disease ended. The exposure to annonaceae acetogenins and/or rotenone has been documented in four of these places, and experimental studies in animals demonstrated annonaceae acetogenins neurotoxicity, which is similar to rotenone neurotoxicity. Simultaneous exposure to acetogenins and rotenone could produce a synergistic toxicity on neurons. (C) 2006 Movement Disorder Society.