Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated Aspergillus flocculosus 16D-1
Asperfloketals A and B, the First Two Ergostanes with Rearranged A and D Rings: From the Sponge-Associated Aspergillus flocculosus 16D-1
复制标题
Asperfloketals A 和 B，前两种具有重新排列的 A 和 D 环的麦角甾烷：来自海绵相关的絮状曲霉 16D –1
DOI：
10.1021/acs.joc.0c02049
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发表时间：
2021-08-20
影响因子：
3.6
通讯作者：
Lin, Hou-Wen
中科院分区：
文献类型：
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作者：
Jiao, Fu-Rong;Gu, Bin-Bin;Lin, Hou-Wen
曲霉酮A(1)和B(2)是从海绵伴生真菌絮状曲霉16D-1中分离得到的两个具有新的三氧六杂环系统的1(10-gt；6)-abo-14，15-secosterone。在DP4+概率分析的支持下，通过广谱分析和核磁共振化学位移计算确定了它们的结构，并用ECD计算和改进的Mosher方法确定了它们的绝对构型。曲霉酮A和B对CuSO4诱导的转基因荧光斑马鱼具有较强的抗炎活性，但对HeLa、HepG2和SW480细胞株无细胞毒性。
Asperfloketals A (1) and B (2), two 1(10 -> 6)-abeo-14,15-secosteroids featuring a novel trioxahexaheterocyclic ring system, were isolated from the sponge-associated fungus Aspergillus flocculosus 16D-1. Their structures were elucidated by extensive spectroscopic analysis and NMR chemical shifts calculations, supported by DP4+ probability analysis, and their absolute configurations were determined by ECD calculations and the modified Mosher's method. Asperfloketals A and B showed strong anti-inflammatory activity in the CuSO4-induced transgenic fluorescent zebrafish but displayed no cytotoxicity against HeLa, HepG2, and SW480 cell lines.