Amoeboid swimming in a compliant channel.
Amoeboid swimming in a compliant channel.
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变形虫在顺应的通道中游泳。
DOI：
10.1039/c9sm01689a
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发表时间：
2020
期刊：
影响因子：
3.4
通讯作者：
C. Misbah
中科院分区：
文献类型：
--
作者：
S. Dalal;A. Farutin;C. Misbah
一些原核生物和真核细胞在形成限制的可变形和刚性表面中游泳。生物系统中最常见的例子是血液悬浮液中的白细胞和病原体通过微血管网络的运动，以及真核细胞（例如免疫系统细胞和癌细胞）通过间质组织内的软间质细胞和细胞外基质之间的间隙的运动。这促使我们对变形虫在柔性通道中游泳的流动动力学进行数值研究。研究了壁刚度和通道限制对流动动力学和游泳者运动的影响。与刚性通道相比，游泳者通过柔性通道的运动显着减慢。充分灵活的通道中的强大限制通过严格限制游泳者的向前运动来囚禁游泳者。刚性通道中的游泳者速度显示出随限制的非单调变化，而在高度灵活的通道中则显示出单调减少。使用游泳者显示的瞬时流场和流动历史来说明柔性和刚性通道中这种不同速度行为背后的物理原理。这种行为是由游泳者表现出的形状变化和墙壁顺应性之间微妙的相互作用产生的。这项研究可能有助于了解周围环境的弹性对免疫监视和癌细胞侵袭性中细胞运动的影响。
Several prokaryotes and eukaryotic cells swim in the presence of deformable and rigid surfaces that form confinement. The most commonly observed examples from biological systems are motility of leukocytes and pathogens present within the blood suspension through a microvascular network, and locomotion of eukaryotic cells such as immune system cells and cancerous cells through interstices between soft interstitial cells and the extracellular matrix within the interstitial tissue. This motivated us to investigate numerically the flow dynamics of amoeboid swimming in a flexible channel. The effects of wall stiffness and channel confinement on the flow dynamics and swimmer motion are studied. The swimmer motion through the flexible channel is substantially decelerated compared to the rigid channel. The strong confinement in the amply flexible channel imprisons the swimmer by severely restricting its forward motion. The swimmer velocity in a stiff channel displays nonmonotonic variation with the confinement while it shows monotonic reduction in a highly flexible channel. The physical rationale behind such distinct velocity behaviour in flexible and rigid channels is illustrated using an instantaneous flow field and flow history displayed by the swimmer. This behavior follows from a subtle interplay between the shape changes exhibited by the swimmer and the wall compliance. This study may aid in understanding the influence of elasticity of the surrounding environment on cell motility in immunological surveillance and invasiveness of cancer cells.
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影响因子：
11.2
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