Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods.
Health-related quality of life, assessed with a disease-specific questionnaire, in Swedish adults suffering from well-diagnosed food allergy to staple foods.
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DOI：
10.1186/2045-7022-3-21
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发表时间：
2013-01-01
影响因子：
4.4
通讯作者：
Ahlstedt, Staffan
中科院分区：
文献类型：
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作者：
Jansson, Sven-Arne;Heibert-Arnlind, Marianne;Ahlstedt, Staffan
背景：我们的目的是调查影响成年瑞典食物过敏患者健康相关生活质量(HRQL)的因素，这些患者客观地被诊断为对主食牛奶、鸡蛋或小麦中的至少一种过敏。对所涉及的食物的数量、症状的类型和严重程度以及伴随的过敏性疾病进行评估。方法：使用EuroPrevall开发的疾病特异性食物过敏生活质量问卷(FAQLQ-AF)。问卷有四个领域：过敏原避免和饮食限制(AADR)、情绪影响(EI)、意外暴露风险(RAE)和食物过敏相关健康(FAH)。与一般问卷EuroQol健康问卷5个维度(EQ-5D)的结果进行比较。这些患者是在一家门诊过敏诊所招募的，基于令人信服的食物过敏史，并补充了对相关食物的特异性IgE分析。79例患者中，男性28例，女性51例，平均年龄41岁。结果：对HRQL影响最大的领域是AADR，评估患者的饮食限制体验。对HRQL影响最小的领域是FAH，与食物过敏引起的健康问题有关。三分之一的患者有四种相伴的过敏性疾病，这对HRQL有负面影响。此外，哮喘与食物过敏的结合产生了强烈的影响。过敏反应，尤其是肾上腺素自动注射器的处方，与低HRQL有关。而使用EQ-5D则看不到这些影响。症状分析表明，口腔过敏综合征和心血管症状对HRQL的影响最大。结论：FAQLQ-AF是一种有效的工具，与常用的通用EQ-5D相比，FAQLQ-AF在主食过敏患者中更准确。它增加了有关食物过敏性成年人的HRQL的重要信息。我们发现，饮食对患者的限制对HRQL的负面影响最大。食物过敏的严重程度和伴随的过敏性疾病的存在都对HRQL有深远的影响。
BACKGROUND: Our aim was to investigate the factors that affect health related quality of life (HRQL) in adult Swedish food allergic patients objectively diagnosed with allergy to at least one of the staple foods cow's milk, hen's egg or wheat. The number of foods involved, the type and severity of symptoms, as well as concomitant allergic disorders were assessed.METHODS: The disease-specific food allergy quality of life questionnaire (FAQLQ-AF), developed within EuroPrevall, was utilized. The questionnaire had four domains: Allergen Avoidance and Dietary Restrictions (AADR), Emotional Impact (EI), Risk of Accidental Exposure (RAE) and Food Allergy related Health (FAH). Comparisons were made with the outcome of the generic questionnaire EuroQol Health Questionnaire, 5 Dimensions (EQ-5D). The patients were recruited at an outpatient allergy clinic, based on a convincing history of food allergy supplemented by analysis of specific IgE to the foods in question. Seventy-nine patients participated (28 males, 51 females, mean-age 41years).RESULTS: The domain with the most negative impact on HRQL was AADR, assessing the patients' experience of dietary restrictions. The domain with the least negative impact on HRQL was FAH, relating to health concerns due to the food allergy. One third of the patients had four concomitant allergic disorders, which had a negative impact on HRQL. Furthermore, asthma in combination with food allergy had a strong impact. Anaphylaxis, and particularly prescription of an epinephrine auto-injector, was associated with low HRQL. These effects were not seen using EQ-5D. Analyses of the symptoms revealed that oral allergy syndrome and cardiovascular symptoms had the greatest impact on HRQL. In contrast, no significant effect on HRQL was seen by the number of food allergies.CONCLUSIONS: The FAQLQ-AF is a valid instrument, and more accurate among patients with allergy to staple foods in comparison to the commonly used generic EQ-5D. It adds important information on HRQL in food allergic adults. We found that the restrictions imposed on the patients due to the diet had the largest negative impact on HRQL. Both severity of the food allergy and the presence of concomitant allergic disorders had a profound impact on HRQL.