Postnatal exposure to chlorinated dioxins and related chemicals on lymphocyte subsets in Japanese breast-fed infants
Postnatal exposure to chlorinated dioxins and related chemicals on lymphocyte subsets in Japanese breast-fed infants
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DOI：
10.1016/s0045-6535(98)00243-4
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发表时间：
1998-10-01
期刊：
影响因子：
8.8
通讯作者：
Watanabe, T
中科院分区：
文献类型：
--
作者：
Nagayama, J;Tsuji, H;Watanabe, T
研究了出生后暴露于多氯二苯并对二恶英(PCDDs)、多氯二苯并呋喃(PCDFs)和共面多氯联苯(Co-PCbs)对36名母乳喂养的日本婴儿外周血淋巴细胞亚群的影响。因此，从母乳中估计这些化学物质的毒性当量(TEQ)转化为2，3，7，8-四氯二苯并-对二恶英(2，3，7，8-TCDD)当量的估计总摄入量与母乳喂养婴儿血液中CD4+和CD8+淋巴细胞的百分比呈正相关和负相关。因此，随着估计的TEQ总摄入量，CD4+/CD8+T细胞的比率呈现出显著的上升趋势。因此，我们的研究表明，通过母乳暴露于本底水平的剧毒有机氯化合物会影响人类新生儿的免疫系统。(C)1998爱思唯尔科学有限公司。保留所有权利。
Effects of postnatal exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (Co-PCBs) on lymphocyte subpopulations were investigated in the peripheral blood of 36 breast-fed Japanese babies. As a result, estimated total intakes of these chemicals in toxic equivalent quantity (TEQ) converted into 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3, 7,8-TCDD) equivalents from the breast milk positively and negatively correlated with the respective percentages of CD4+ and CD8+ lymphocytes in the blood of breast-fed babies. Consequently, the ratios of CD4+ to CD8+ T cells showed significant increasing tendency with the estimated total TEQ intakes. Therefore, our study suggests that exposure to background levels of the highly toxic organochlorine compounds through the breast milk influences the human neonatal immune system. (C) 1998 Elsevier Science Ltd. All rights reserved.