Cervical cancer in the Netherlands 1989-1998: Decrease of squamous cell carcinoma in older women, increase of adenocarcinoma in younger women
Cervical cancer in the Netherlands 1989-1998: Decrease of squamous cell carcinoma in older women, increase of adenocarcinoma in younger women
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DOI：
10.1002/ijc.20678
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发表时间：
2005-03-01
影响因子：
6.4
通讯作者：
Meijer, CJLM
中科院分区：
文献类型：
--
作者：
Bulk, S;Visser, O;Meijer, CJLM
宫颈癌是一种可预防的疾病，多发于相对年轻的妇女。在荷兰，以人口为基础的子宫颈筛查针对30-60岁的妇女。我们对荷兰浸润性宫颈癌的发病率进行了一项基于人群的研究，以评估其趋势，重点是诊断时的年龄。从荷兰癌症登记处检索1989年1月1日至1998年12月31日期间所有居住在荷兰的浸润性宫颈癌妇女的组织学诊断。在这10年期间，鳞状细胞癌的发病率从7.1/10万显著下降到6.1/10万（p < 0.001），其中60-74岁女性下降幅度最大（-5.5%）。虽然腺癌的总体发病率保持稳定，但15-29岁女性的发病率增加（+15.8%），30-44岁女性的发病率增加（+2.5%），尽管病例数量很少。对于鳞状细胞癌，诊断时11期的发病率下降最多（-2.7%）。腺癌的诊断分期没有变化。大多数子宫颈癌病例（60.5%）是在30至60岁之间发现的，即荷兰筛查的年龄间隔。30岁以下妇女的子宫颈癌占总发病率的5.0%，其中3.0%发生在27至29岁之间。因此，在荷兰，宫颈癌筛查与鳞状细胞癌发病率的下降有关，而腺癌发病率似乎在年轻女性中有所增加。(C) 2004 Wiley-Liss, Inc。
Cervical cancer is a preventable disease, occurring in relatively young women. In the Netherlands, population-based cervical screening aims at women aged 30-60 years. We performed a population-based study of the incidence of invasive cervical cancer in the Netherlands to evaluate trends, with emphasis on age at time of diagnosis. Histologic diagnosis was retrieved from the Netherlands Cancer Registry for all women residing in the Netherlands with invasive cervical cancer between January 1, 1989, and December 31, 1998. In this 10-year period, the incidence rate of squamous cell carcinoma decreased significantly from 7.1/100,000 to 6.1/100,000 (p < 0.001), with the greatest decrease in women aged 60-74 (-5.5%). While the overall incidence rate of adenocarcinoma remained stable, it increased in women aged 15-29 (+15.8%) and in women aged 30-44 (+2.5%), though the number of cases was small. For squamous cell carcinoma, the incidence of stage 11 at diagnosis decreased most (-2.7%). There was no change in stage at diagnosis for adenocarcinoma. Most cases of cervical cancer, 60.5%, were detected between ages 30 and 60 years, i.e., the Dutch screening age interval. Cervical cancer in women below age 30 contributed 5.0% to the total incidence, with 3.0% occurring between ages 27 and 29. Thus, screening for cervical cancer in the Netherlands is associated with a decrease in the incidence of squamous cell carcinoma and adenocarcinoma incidence appears to be increasing in younger women. (C) 2004 Wiley-Liss, Inc.