High contrast power Doppler imaging in side-viewing intravascular ultrasound imaging via angular compounding.
High contrast power Doppler imaging in side-viewing intravascular ultrasound imaging via angular compounding.
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DOI：
10.1016/j.ultras.2020.106200
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发表时间：
2020-12
期刊：
影响因子：
4.2
通讯作者：
Lindsey BD
中科院分区：
文献类型：
--
作者：
Collins GC;Jing B;Lindsey BD
评估斑块破裂可能性的能力可以决定冠状动脉疾病的治疗过程。斑块脆弱性的一个指标是斑块内血管的发展，或斑块内新血管形成。为了在心导管实验室中以更高的灵敏度可视化这些血管，提出了一种使用侧视血管内超声（IVUS）对小血管中的血流进行成像的新方法。在组织模拟体模和离体血管中评价了这种基于复合相邻角度采集的方法。在体模研究中，由于应用角度复合，多普勒CNR从3.3 ± 1.0增加到13 ± 2.6（传统杂波滤波），从1.9 ± 0.15增加到7.5 ± 1.1（SVD滤波）。当在离体猪动脉管腔附近的200 μm管中以5.6 mm/s的速率成像血流时，多普勒CNR从5.3 ± 0.95增加到7.2 ± 1.3（常规滤波），从23 ± 3.3增加到32 ± 6.7（SVD滤波）。应用这些策略可以提高侧视血管内超声成像对慢血流的灵敏度。
The ability to assess likelihood of plaque rupture can determine the course of treatment in coronary artery disease. One indicator of plaque vulnerability is the development of blood vessels within the plaque, or intraplaque neovascularization. In order to visualize these vessels with increased sensitivity in the cardiac catheterization lab, a new approach for imaging blood flow in small vessels using side-viewing intravascular ultrasound (IVUS) is proposed. This approach based on compounding adjacent angular acquisitions was evaluated in tissue mimicking phantoms and ex vivo vessels. In phantom studies, the Doppler CNR increased from 3.3 ± 1.0 to 13 ± 2.6 (conventional clutter filtering) and from 1.9 ± 0.15 to 7.5 ± 1.1 (SVD filtering) as a result of applying angular compounding. When imaging flow at a rate of 5.6 mm/s in 200 μm tubes adjacent to the lumen of ex vivo porcine arteries, the Doppler CNR increased from 5.3 ± 0.95 to 7.2 ± 1.3 (conventional filtering) and from 23 ± 3.3 to 32 ± 6.7 (SVD filtering). Applying these strategies could allow increased sensitivity to slow flow in side-viewing intravascular ultrasound imaging.
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