Three-dimensional bioprinting vascularized bone tissue
Three-dimensional bioprinting vascularized bone tissue
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DOI：
10.1557/s43577-023-00547-y
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发表时间：
2023-06
期刊：
影响因子：
5
通讯作者：
Hadis Gharacheh;M. Guvendiren
中科院分区：
文献类型：
--
作者：
Hadis Gharacheh;M. Guvendiren
目前已有的骨移植材料不足以满足需求，缺乏组织的复杂性来模拟天然的骨组织微环境。骨组织是高度血管性的，而血管对骨组织的发育和移植到天然缺损处的功能整合是至关重要的。三维生物打印是一种先进的生物制造技术，用于开发具有结构、结构、生化和细胞复杂性的血管化骨组织。本文包括目前可用的3D生物打印技术和相应的生物墨水，然后详细回顾了用于血管系统的3D生物打印策略。最后，介绍了血管化骨组织三维生物打印技术的现状。
Currently available bone grafts are insufficient to address the demand and lack tissue complexity to mimic the native bone tissue microenvironment. Bone tissue is highly vascular, and vasculature is crucial for bone tissue development and functional integration of the graft to the native defect site. Three-dimensional (3D) bioprinting has emerged as an advanced biomanufacturing technology to develop vascularized bone tissue with architectural, structural, biochemical, and cellular complexity. This article includes currently available 3D bioprinting technologies and corresponding bioinks followed by a detailed review on 3D bioprinting strategies for vasculature. Finally, the current state of the art in 3D bioprinting of vascularized bone tissue is presented.