GLUTAMATERGIC TREATMENT STRATEGIES FOR AGE-RELATED MEMORY DISORDERS
GLUTAMATERGIC TREATMENT STRATEGIES FOR AGE-RELATED MEMORY DISORDERS
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DOI：
10.1016/0024-3205(94)00395-5
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发表时间：
1994-01-01
期刊：
影响因子：
6.1
通讯作者：
STOLL, S
中科院分区：
文献类型：
--
作者：
MULLER, WE;SCHEUER, K;STOLL, S
Age-related changes of N-methyl-D-aspartate (NMDA) receptors have been found in cortical areas and in the hippocampus of many species. On the basis of a variety of experimental observations it has been suggested that the decrease of NMDA receptor density might be one of the causative factors of the cognitive decline with aging. Based on these findings several strategies have been developed to improve cognition by compensating the NMDA receptor deficits in aging. The most promising approaches are the indirect activation of glutamatergic neurotransmission by agonists of the glycine site or the restoration of the age-related deficit of receptor density by several nootropics.
