Fast mapping of myocardial blood flow with MR first-pass perfusion imaging
Fast mapping of myocardial blood flow with MR first-pass perfusion imaging
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DOI：
10.1002/mrm.21559
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发表时间：
2008-06-01
影响因子：
3.3
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
Goldstein, Thomas A.;Jerosch-Herold, Michael;Zheng, Jie
由于相对较长的计算时间和对噪声敏感的算法，使用MR首遍灌注成像技术在逐像素的基础上准确快速地定量心肌血流量（MBF）仍然很困难。在本研究中，利用Zierler的中心体积原理开发了一种计算MBF的算法，该算法对残差曲线形状的假设很少。通过仿真验证了该算法在确定MBF时的准确性。为了在体内检验我们的算法，我们在9只正常的狗身上进行了研究。在静息和双嘧达莫诱导的血管舒张期间给予血管内造影剂Gadomer，进行两次首次灌注成像。同时注射放射性标记微球测量MBF。使用MR方法测量的狗的MBF与微球测量结果具有良好的相关性（R-2 = 0.96，斜率= 0.9），表明在静息和血管舒张应激期间的灌注测量具有相当的准确性。除了准确性外，该方法还可以优化运行速度，为临床环境中快速准确的心肌灌注制图提供可能。
Accurate and fast quantification of myocardial blood flow (MBF) with MR first-pass perfusion imaging techniques on a pixel-bypixel basis remains difficult due to relatively long calculation times and noise-sensitive algorithms. In this study, Zierler's central volume principle was used to develop an algorithm for the calculation of MBF with few assumptions on the shapes of residue curves. Simulation was performed to evaluate the accuracy of this algorithm in the determination of MBF. To examine our algorithm in vivo, studies were performed in nine normal dogs. Two first-pass perfusion imaging sessions were performed with the administration of the intravascular contrast agent Gadomer at rest and during dipyridamole-induced vasodilation. Radiolabeled microspheres were injected to measure MBF at the same time. MBF measurements in dogs using MR methods correlated well with the microsphere measurements (R-2 = 0.96, slope = 0.9), demonstrating a fair accuracy in the perfusion measurements at rest and during the vasodilation stress. In addition to its accuracy, this method can also be optimized to run relatively fast, providing potential for fast and accurate myocardial perfusion mapping in a clinical setting.