Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease
Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease
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DOI：
10.1016/j.jneuroim.2005.10.008
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Zerr, I
中科院分区：
文献类型：
--
作者：
Stoeck, K;Bodemer, M;Zerr, I
We investigated cerebrospinal fluid (CSF) samples from patients with Creutzfeldt-Jakob disease (CJD) and other neurological diseases.Concentrations of pro- and anti-inflammatory cytokines IL-1 beta, IL-6, IL-8, IL-12, TNF-alpha and TGF-beta 2 were determined in CSF using ELISA.Significantly changes were found for IL-8 and TGF-beta 2. IL-8 levels were elevated in the CSF of CJD patients. Of interest, the increase was significant to other dementia and to controls. In contrast, TGF-beta 2 was significantly decreased in CSF of CJD compared to all groups. IL-1 beta IL-12 and TNF-alpha could not be detected in CSF or in case of IL-6 in only low concentrations without significant difference. (C) 2005 Elsevier B.V. All rights reserved.
