Sex Steroid Receptors in Immune Cells
Sex Steroid Receptors in Immune Cells
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DOI：
10.1007/978-3-642-02155-8_3
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发表时间：
2010-01-01
期刊：
影响因子：
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通讯作者：
Agrawal, Hemant
中科院分区：
文献类型：
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作者：
Kovats, Susan;Carreras, Esther;Agrawal, Hemant
淋巴细胞和骨髓细胞表达雌激素、孕激素和雄激素受体，研究表明性类固醇激素在先天性和适应性免疫过程中直接调节它们的激活、寿命和功能反应。造血祖细胞也表达雌激素和雄激素受体，并且已报道性激素对淋巴和骨髓细胞发育的深远影响。性类固醇受体通过多种配体依赖性或配体独立机制充当核转录因子。性类固醇受体还介导与膜受体信号传导协同作用的快速信号传导事件。通过确定性类固醇受体信号调节免疫细胞发育和功能的潜在不同分子机制，可以阐明基于性别的免疫差异的基础。
Lymphocytes and myeloid cells express estrogen, progesterone, and androgen receptors, and studies show that sex steroid hormones directly modulate their activation, lifespan, and functional response during innate and adaptive immunity. Hematopoietic progenitors also express estrogen and androgen receptors, and profound effects of sex hormones on development of lymphoid and myeloid cells have been reported. The sex steroid receptors act as nuclear transcription factors, via multiple ligand-dependent or ligand-independent mechanisms. Sex steroid receptors also mediate rapid signaling events that synergize with membrane receptor signaling. The basis of sex-based differences in immunity will be clarified by determination of the potentially diverse molecular mechanisms by which sex steroid receptor signaling regulates immune cell development and function.