Immunotoxins: a new approach to cancer therapy.
Immunotoxins: a new approach to cancer therapy.
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免疫毒素：癌症治疗的新方法。
DOI：
10.1126/science.6218613
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Uhr,JW
中科院分区：
文献类型：
--
作者：
Vitetta,ES;Krolick,KA;Miyama-Inaba,M;Cushley,W;Uhr,JW
肿瘤反应性抗体和毒素(免疫毒素)的结合物已被用于在体外和体内清除肿瘤细胞。这种免疫毒素可以高效地杀死浸润性骨髓中的小鼠白血病细胞，在治疗癌症的骨髓救援方法中应该是有用的。类似的免疫毒素可诱导白血病小鼠的长期缓解，而含有抗原的免疫毒素可在体外诱导正常小鼠脾细胞的免疫无反应。因此，父母使用免疫毒素的长期目标包括在体内杀死癌细胞和出于治疗目的调节免疫反应。
Conjugates of tumor-reactive antibody and toxins (immunotoxins) have been used to eradicate tumor cells in vitro and in vivo. Such immunotoxins are highly effective in killing murine leukemic cells in infiltrated bone marrow and should be useful in the bone marrow rescue approach for the treatment of cancer. Similar immunotoxins injected parentally can help to induce prolonged remissions in leukemic mice, and antigen-containing immunotoxins can induce immunologic unresponsiveness in vitro in normal murine splenocytes. Thus, long-range goals for the parental use of immunotoxins include the killing of cancer cells in vivo and the modulation of the immune response for therapeutic purposes.