NORADRENALINE, ATRIAL NATRIURETIC PEPTIDE, BOMBESIN AND NEUROTENSIN IN MYOCARDIUM AND BLOOD OF RATS IN CONGESTIVE CARDIAC-FAILURE
NORADRENALINE, ATRIAL NATRIURETIC PEPTIDE, BOMBESIN AND NEUROTENSIN IN MYOCARDIUM AND BLOOD OF RATS IN CONGESTIVE CARDIAC-FAILURE
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DOI：
10.1093/cvr/23.8.674
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发表时间：
1989-08-01
影响因子：
10.8
通讯作者：
HARRIS, P
中科院分区：
文献类型：
--
作者：
CECONI, C;CONDORELLI, E;HARRIS, P
给予野百合碱的大鼠发生严重的右心室肥大，通常伴有腹水和胸腔积液。在右心室肥大且无浆液性积液的大鼠（“肥大”组）中，心室去甲肾上腺素浓度降低，但心室内容物不变。心房去甲肾上腺素浓度不受影响。那些右心室肥大和浆液性渗出更严重的人（“衰竭”组），所有四个心室的去甲肾上腺素浓度都大大降低，特别是在右侧;右心室和左心室的去甲肾上腺素含量也减少了。本文报道了ir-ANP、ir-bombesin和ir-neurotensin在正常大鼠心脏的分布。ANP浓度下降到33%，在右心房和左心房的“失败”的动物和57%，在右心房的“肥大”的动物的46%。正常情况下，右心室ANP含量较低，两组均增加两倍以上，浓度保持不变。“衰竭”组左心室心钠素含量降低。蛙皮素和神经降压素的浓度下降，在两组的两个心室。蛙皮素含量无变化，但神经降压素含量下降，尤其是在右侧。血浆ANP上升近6倍，而血浆蛙皮素和神经降压素下降的“失败”组。“肥大”组的血浆肽浓度不变。这些研究表明野百合碱模型在区分肥大效应和与充血性心力衰竭综合征特异性相关效应方面的实用性。
Rats given monocrotaline develop severe right ventricular hypertrophy often accompanied by ascites and pleural effusions. In rats with right ventricular hypertrophy and no serous effusions ("hypertrophy" group), ventricular concentrations of noradrenaline were reduced but ventricular contents were unchanged. Atrial conentrations of noradrenaline were unaffected. Those with more severe right ventricular hypertrophy and serous effusions ("failure" group) had greatly reduced concentrations of noradrenaline in all four chambers, particularly on the right side; the right and left ventricular contents of noradrenaline were also diminished. The distributions of ir-ANP, ir-bombesin and ir-neurotensin in the normal rat heart are presented. ANP concentration fell to 33% in the right atrium and 46% in the left atrium of "failure" animals and to 57% in the right atrium of "hypertrophy" animals. Right ventricular content of ANP, normally low, increased more than two-fold in both groups, the concentration remaining unchanged. Left ventricular content of ANP decreased in the "failure" group. Concentrations of bombesin and neurotensin fell in both ventricles of both groups. Ventricular contents of bombesin did not change, but ventricular contents of neurotensin decreased, especially on the right side. Plasma ANP rose nearly six-fold while plasma bombesin and neurotensin fell in the "failure" group. Plasma peptide concentrations were unchanged in the "hypertrophy" group. The studies show the utility of the monocrotaline model in distinguishing between the effects of hypertrophy and those associated specifically with the syndrome of congestive cardiac failure.