Growth development of French children born after in vitro maturation.
Growth development of French children born after in vitro maturation.
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DOI：
10.1371/journal.pone.0089713
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Labrune P
中科院分区：
文献类型：
--
作者：
Foix-L'Hélias L;Grynberg M;Ducot B;Frydman N;Kerbrat V;Bouyer J;Labrune P
多项证据表明，在辅助生殖技术 (ART) 中，不成熟卵母细胞取出和随后的体外成熟 (IVM)（无需卵巢刺激）可能是可靠的选择。然而，采用这种技术出生的孩子的结果数据很少。我们评估了 IVM 后怀孕的法国儿童的身高和体重发育。所有在 Antoine Beclere 医院（法国克拉马尔）进行 IVM 后受孕并于 2003 年 6 月至 2008 年 10 月期间出生的儿童 (n = 38) 均纳入一项前瞻性队列研究，并与未进行 IVM 的 ICSI 受孕儿童的对照组进行比较，并匹配母亲年龄、胎龄和单胎/双胎妊娠。随访包括一年时的临床检查和孩子两岁时家长填写的问卷（随访率97%）。对于男孩来说，IVM 和对照组之间没有发现统计学差异。 IVM 女孩的出生时平均体重、身高和头围显着大于 ICSI 女孩（分别为 3.236 公斤 vs 2.701 公斤 (p = 0.03)；49 厘米 vs 47 厘米 (p = 0.01) 和 34 厘米 vs 33 厘米 (p = 0.04)）。一年时，IVM 女孩仍然较重（平均体重 10.2 公斤 vs 8.6 公斤 (p = 0.001)），身高较高（76 厘米 vs 73 厘米 (p = 0.03)），两组女孩之间的 BMI 存在两点差异（18 vs 16 (p = 0.01)）。我们对 IVM 后出生的女孩的结果应谨慎解释。目前尚不清楚观察到的性别二态性是由于 IVM 技术还是由于多囊卵巢综合征 (PCOS) 患者潜在不孕等母亲特征所致。需要进一步监测这些婴儿的结果。
Several lines of evidence indicate that immature oocyte retrieval and subsequent in vitro maturation (IVM) without ovarian stimulation may be a reliable option in assisted reproductive technologies (ART). However, few outcome data are available for children born following this technique. We assessed height and weight development of French children conceived after IVM. All children conceived after IVM at Antoine Beclere Hospital (Clamart, France) and born between June 2003 and October 2008 (n = 38) were included in a prospective cohort study and compared with a control group of children conceived by ICSI without IVM, matched for maternal age, gestational age and singleton/twin pregnancies. Follow-up included clinical examination at one year and a questionnaire completed by parents when the children were two years old (97% follow-up rate). No statistical differences between IVM and control groups were found for boys. Mean weight, height and head circumference at birth were significantly greater for IVM than for ICSI girls (3.236 kg vs 2.701 kg (p = 0.03); 49 cm vs 47 cm (p = 0.01) and 34 cm vs 33 cm (p = 0.04), respectively). At one year, IVM girls remained heavier (mean weight 10.2 kg vs 8.6 kg (p = 0.001)) and taller (76 cm vs 73 cm (p = 0.03)), and there was a two-point difference in BMI between the two groups of girls (18 vs 16 (p = 0.01)). Our results in girls born after IVM should be interpreted with caution. It remains unclear whether the observed sexual dimorphism is due to IVM technology or to maternal characteristics such as underlying infertility in patients with polycystic ovary syndrome (PCOS). Further monitoring of the outcomes of these infants is required.
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DOI：
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发表时间：
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