Glioblastoma multiforme: Diagnosis, treatment, and invasion.
Glioblastoma multiforme: Diagnosis, treatment, and invasion.
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DOI：
10.7555/jbr.36.20220156
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发表时间：
2022-10-28
影响因子：
2.3
通讯作者：
Lu Y
中科院分区：
文献类型：
--
作者：
Li J;Feng L;Lu Y
多形性胶质母细胞瘤（GBM）是一种基本上不可治愈的脑肿瘤，其已经被探索了大约世纪。目前，手术切除、化疗和放射治疗仍是标准的治疗选择。然而，由于胶质母细胞瘤固有的侵袭和转移特征以及对化疗的抵抗，其患者的生存率仍不令人满意。为了改善目前的状况，需要更多的研究来提供GBM的全面知识。本文就胶质母细胞瘤的治疗和侵袭的最新进展作一综述。首先，我们回顾了用于GBM治疗的传统和新兴疗法。鉴于这些治疗方法的疗效有限，我们将进一步讨论侵袭在GBM复发和进展中的作用，并介绍目前GBM侵袭方式和机制的研究进展。
Glioblastoma multiforme (GBM) is an essentially incurable brain tumor, which has been explored for approximately a century. Nowadays, surgical resection, chemotherapy, and radiation therapy are still the standardized therapeutic options. However, due to the intrinsic invasion and metastasis features and the resistance to chemotherapy, the survival rate of glioblastoma patients remains unsatisfactory. To improve the current situation, much more research is needed to provide comprehensive knowledge of GBM. In this review, we summarize the latest updates on GBM treatment and invasion. Firstly, we review the traditional and emerging therapies that have been used for GBM treatment. Given the limited efficiency of these therapies, we further discuss the role of invasion in GBM recurrence and progression, and present current research progress on the mode and mechanisms of GBM invasion.