Microbubble transport through a bifurcating vessel network with pulsatile flow.
Microbubble transport through a bifurcating vessel network with pulsatile flow.
复制标题
微泡通过脉动流的分叉血管网络传输。
DOI：
10.1007/s10544-011-9591-x
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发表时间：
2012
影响因子：
2.8
通讯作者：
Bull,JosephL
中科院分区：
文献类型：
--
作者：
Valassis,DougT;Dodde,RobertE;Esphuniyani,Brijesh;Fowlkes,JBrian;Bull,JosephL
出于两相微流体和空气栓塞和发展气体栓塞治疗技术的临床应用，脉动流中的微泡运输的实验和理论模型。一维时间相关的理论模型是从非定常伯努利方程，已被修改，包括粘性和非定常的影响。实验和理论结果表明，横摇角（分叉网络平面与水平面的夹角）是影响分叉网络内各分叉处气泡分裂比的重要因素。当与相应的恒定流相比时，脉动流显示出对气泡的总体分裂比产生不显著的变化，尽管Womersley数为一阶，这表明通过脉管系统的气泡分裂可以用更适度的恒定流模型充分建模。而气泡的滞留则受流体脉动的影响，脉动流的影响与气泡长度的分裂比有关。气泡在分叉处达到稳定状态后保持滞留的能力对于气体栓塞治疗阻塞流向肿瘤的血流的有效性是有希望的，并且表明理解在空气栓塞中何处将发生滞留的重要性。证明了在分叉网络内的不稳定流中准确预测气泡动力学的能力，并表明微流体装置中的气泡在其动力学的稳定和不稳定方面编码信息的潜力。
Motivated by two-phase microfluidics and by the clinical applications of air embolism and a developmental gas embolotherapy technique, experimental and theoretical models of microbubble transport in pulsatile flow are presented. The one-dimensional time-dependent theoretical model is developed from an unsteady Bernoulli equation that has been modified to include viscous and unsteady effects. Results of both experiments and theory show that roll angle (the angle the plane of the bifurcating network makes with the horizontal) is an important contributor to bubble splitting ratio at each bifurcation within the bifurcating network. When compared to corresponding constant flow, pulsatile flow was shown to produce insignificant changes to the overall splitting ratio of the bubble despite the order one Womersley numbers, suggesting that bubble splitting through the vasculature could be modeled adequately with a more modest constant flow model. However, bubble lodging was affected by the flow pulsatility, and the effects of pulsatile flow were evident in the dependence of splitting ratio of bubble length. The ability of bubbles to remain lodged after reaching a steady state in the bifurcations is promising for the effectiveness of gas embolotherapy to occlude blood flow to tumors, and indicates the importance of understanding where lodging will occur in air embolism. The ability to accurately predict the bubble dynamics in unsteady flow within a bifurcating network is demonstrated and suggests the potential for bubbles in microfluidics devices to encode information in both steady and unsteady aspects of their dynamics.