CARCINOMA OF THE VAGINA - EXPERIENCE AT THE PRINCESS-MARGARET-HOSPITAL (1974-1989)
CARCINOMA OF THE VAGINA - EXPERIENCE AT THE PRINCESS-MARGARET-HOSPITAL (1974-1989)
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DOI：
10.1006/gyno.1995.1077
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发表时间：
1995-03-01
影响因子：
4.7
通讯作者：
SIMMS, J
中科院分区：
文献类型：
--
作者：
KIRKBRIDE, P;FYLES, A;SIMMS, J
本文分析了1974年至在玛嘉烈医院就诊的153例阴道癌或原位癌患者的治疗方式、照射剂量和技术、并发症及生存情况。放射治疗128例，其中术后放疗10例，同期化疗26例。总的5年精算特定原因生存率为66%。按病因分期，0期(C-I-S)的5年生存率为100%，I/II期为77%，III/IV期为56%。治疗的晚期并发症很少见，只有12例患者被归类为严重并发症。单因素分析表明，肿瘤大小和分期、组织学分级、患者年龄和放射剂量7000cGy值是预测生存的重要因素，但在多变量分析中，只有肿瘤大小和分期仍有显著意义。51例患者有1-37年前的妇科恶性肿瘤史，其中34例为宫颈癌。放射治疗是治疗所有阶段的阴道癌的有效方法，为了最大限度地控制肿瘤，建议放射治疗剂量至少为7000cGy.(C)1995年学术出版社。
The charts of 153 patients with vaginal carcinoma or carcinoma in situ seen at Princess Margaret Hospital between 1974 and 1989 were analyzed with respect to treatment modality, radiation dose and technique, complications, and survival. One hundred and twenty-eight patients were treated with radiation therapy, of which 10 received radiation postoperatively and 26 concomitant chemotherapy. The overall 5-year actuarial cause-specific survival was 66%. The 5-year cause-specific survivals by stage were Stage 0 (C-I-S) 100%, Stages I/II 77%, and Stages III/IV 56%. Late complications from treatment were infrequent and in only 12 patients were such complications classified as severe. Univariate analysis indicated that size and stage of tumor, histological grade, patient age, and radiation dose > 7000 cGy were significant factors in predicting survival, although in a multivariate analysis only size and stage retained significance. Fifty-one patients had a prior gynecological malignancy arising 1-37 years previously, of which 34 had cervical cancers. Radiotherapy is an effective treatment for all stages of carcinoma of the vagina and doses of at least 7000 cGy are recommended to maximize tumor control. (C) 1995 Academic Press, Inc.