Mitochondria as the target of the pro-apoptotic protein Bax
Mitochondria as the target of the pro-apoptotic protein Bax
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DOI：
10.1016/j.bbabio.2006.05.032
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发表时间：
2006-09-01
影响因子：
4.3
通讯作者：
Vallette, Francois M.
中科院分区：
文献类型：
--
作者：
Er, Ernine;Oliver, Lisa;Vallette, Francois M.
在细胞凋亡期间，线粒体途径的参与涉及线粒体外膜（OMM）的透化，这导致细胞色素c和其他促凋亡蛋白如Smac/DIABLO、AIF、EndoG、Omi/HtraA 2和DDP/TIMM 8a的释放。OMM透化依赖于多结构域Bcl-2家族蛋白如Bax或巴克的活化、易位和寡聚化。本文综述了Bax构象变化的相关因素以及控制Bax进入线粒体的不同结构域的功能。我们还讨论了我们目前对Bax寡聚化的认识，以及细胞凋亡过程中OMM透化的不同模型的分子机制。(c)2006 Elsevier B. V.保留所有权利。
During apoptosis, engagement of the mitochondrial pathway involves the permeabilization of the outer mitochondrial membrane (OMM), which leads to the release of cytochrome c and other apoptogenic proteins such as Smac/DIABLO, AIF, EndoG, Omi/HtraA2 and DDP/TIMM8a. OMM permeabilization depends on activation, translocation and oligomerization of multidomain Bcl-2 family proteins such as Bax or Bak. Factors involved in Bax conformational change and the function(s) of the distinct domains controlling the addressing and the insertion of Bax into mitochondria are described in this review. We also discuss our current knowledge on Bax oligomerization and on the molecular mechanisms underlying the different models accounting for OMM permeabilization during apoptosis. (c) 2006 Elsevier B.V. All rights reserved.