Adenosine A(2a) receptors in the nucleus accumbens modulate prepulse inhibition of the startle response
Adenosine A(2a) receptors in the nucleus accumbens modulate prepulse inhibition of the startle response
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DOI：
10.1097/00001756-199704140-00038
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发表时间：
1997-04-14
期刊：
影响因子：
1.7
通讯作者：
Koch, M
中科院分区：
文献类型：
--
作者：
Hauber, W;Koch, M
通过全身给予阿扑吗啡（APO）（2 mg/kg，i. p.）破坏声惊吓反应（ASR）的前脉冲抑制（PPI）。选择性腺苷A（2a）-受体激动剂CGS 21680（0.05 μ g，每侧1.0 μ l）微输注到延髓核（NAc）中，在全身性载体预处理的动物中没有显著影响，但显著逆转了用APO预处理的大鼠中PPI的破坏。因此，腺苷通过其对NAc中A（2a）受体的作用参与PPI的控制。载脂蛋白诱导的PPI中断被认为是一个动物模型，可用于筛选典型和非典型抗精神病药物。本研究结果进一步支持了A（2a）受体激动剂可能是潜在有用的抗精神病药物的观点。
Prepulse inhibition (PPI) of the acoustic startle response (ASR) was disrupted by systemic administration of apomorphine (APO) (2 mg/kg, i.p.). Microinfusion of the selective adenosine A(2a)-receptor agonist CGS21680 (0.05 mu g in 1.0 mu l per side) into the nucleus accumbens (NAc), had no significant effect in animals with systemic vehicle pretreatment, but significantly reversed the disruption of PPI in rats pretreated with APO. Adenosine is, therefore, involved in the control of PPI through its actions on A(2a) receptors in the NAc. APO-induced disruption of PPI is considered to represent an animal model useful for screening both typical and atypical antipsychotic agents. The present results add further support to the view that A(2a)-receptor agonists may be potentially useful antipsychotic agents.