Multidisciplinary weight management in locoregional breast cancer: results of a phase II study
Multidisciplinary weight management in locoregional breast cancer: results of a phase II study
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DOI：
10.1023/a:1005942017626
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发表时间：
1998-03-01
影响因子：
3.8
通讯作者：
Miller, A
中科院分区：
文献类型：
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作者：
Goodwin, P;Esplen, MJ;Miller, A
61名新诊断的局部乳腺癌(T1-3，NO-1，RIG)女性，初始体重指数(BMI)在20到35公斤/米(2)之间，正在接受标准辅助治疗(化疗、三苯氧胺和/或放射治疗)，被要求避免体重增加(如果初始BMI为125公斤/米(2))或在一年内减重10公斤(如果初始BMI为25-35公斤/米(2))。女性参加了20个小组会议(每周10次，每月10次)，其中包括心理支持-表达小组干预，辅之以个人体重目标，以及营养和锻炼计划。55名未经审查的女性(5名复发，1名死于蛛网膜下腔出血)平均减重0.53+/-3.72公斤。体重减轻幅度最大的是最初超重(体重指数大于或等于25公斤/米(2))减重1.63+/-4.11公斤的女性(与正常体重的女性相比，P=0.0004)，以及那些没有接受化疗的女性减重2.15+/-2.83公斤(与接受化疗的女性相比，P=0.0004)。70.9%的患者达到了预定的成功标准。有氧运动在干预期间显著增加(p=0.00005)，是成功的最强预测因素(每周每多锻炼30分钟，OR1.73，p=0.003)。干预期间卡路里摄入量变化不明显，但脂肪摄入量明显减少，碳水化合物和纤维摄入量显著增加。饮食行为和心理状态显著改善。因此，这种多学科体重管理干预成功地预防了新诊断的局部乳腺癌女性的体重增加，并帮助超重女性减肥。
Sixty-one women with newly diagnosed locoregional breast cancer (T 1-3, NO-1, RIG) having an initial Body Mass Index (BMI) between 20 and 35 kg/m(2) who were receiving standard adjuvant treatment (chemotherapy, tamoxifen, and/or radiation) were asked to avoid weight gain (if initial BMI 125 kg/m(2)) or to lose up to 10 kg (if initial BMI25-35 kg/m(2)) over one year. Women participated in twenty group sessions (10 weekly, 10 monthly) which involved a psychological supportive-expressive group intervention supplemented by individual weight goals, and nutrition and exercise programs.Fifty-five non-censored women (5 developed recurrence, 1 died of a subarachnoid hemorrhage) lost a mean of 0.53 +/- 3.72 kg. Weight loss was greatest in initially overweight women (BMI greater than or equal to 25 kg/m(2)) who lost 1.63 +/- 4.11 kg (p = 0.01 compared to normal weight women) and in those not receiving chemotherapy who lost 2.15 +/- 2.83 kg (p = 0.0004 compared to those receiving chemotherapy). 70.9% met predefined criteria for success. Aerobic exercise increased significantly during the intervention (p = 0.00005) and was the strongest predictor of success (OR 1.73 for each additional 30 minutes of exercise weekly, p = 0.003). Changes in caloric intake were not significant, but fat intake decreased and carbohydrate and fibre intake increased significantly during the intervention. Eating behavior and psychological status improved significantly.Thus, this multidisciplinary weight management intervention successfully prevented weight gain in women with newly diagnosed locoregional breast cancer, and helped overweight women lose weight.