Corticomotoneuronal cells are "functionally tuned".
Corticomotoneuronal cells are "functionally tuned".
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DOI：
10.1126/science.aaa8035
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发表时间：
2015-11-06
期刊：
影响因子：
--
通讯作者：
Strick PL
中科院分区：
文献类型：
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作者：
Griffin DM;Hoffman DS;Strick PL
初级运动神经元(M1)中的皮质突触神经元(CM)细胞与运动神经元有单突触联系。它们是直接影响电机输出的少数下行指令来源之一。我们研究了CM细胞在其目标肌肉中产生活动的贡献。许多CM细胞的首选方向与其靶肌肉的方向不同。当肌肉作为激动剂时，一些CM细胞被选择性地激活。当同样的肌肉被用作增效剂、固定剂或拮抗剂时，另一些肌肉选择性地活跃。这些观察表明，肌肉的不同功能用途是由不同群体的CM细胞产生的。我们认为，肌肉功能是M1输出中所代表的维度之一。
Corticomotoneuronal (CM) cells in the primary motor cortex (M1) have monosynaptic connections with motoneurons. They are one of the few sources of descending commands that directly influence motor output. We examined the contribution of CM cells to the generation of activity in their target muscles. The preferred direction of many CM cells differed from that of their target muscles. Some CM cells were selectively active when a muscle was used as an agonist. Others were selectively active when the same muscle was used as a synergist, fixator, or antagonist. These observations suggest that the different functional uses of a muscle are generated by separate populations of CM cells. We propose that muscle function is one of the dimensions represented in the output of M1.