Nongenomic actions of adrenal steroids in the central nervous system.
Nongenomic actions of adrenal steroids in the central nervous system.
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DOI：
10.1111/j.1365-2826.2010.02000.x
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发表时间：
2010-08
影响因子：
3.2
通讯作者：
Krause EG
中科院分区：
文献类型：
--
作者：
Evanson NK;Herman JP;Sakai RR;Krause EG
矿化皮质激素和糖皮质激素是肾上腺皮质在应激和水矿物质失衡时释放的类固醇激素。从历史上看，肾上腺皮质类固醇的作用归因于对基因转录的影响。然而，最近，它已经变得清楚，基因组独立的途径代表了肾上腺类固醇作用的一个重要方面。这些激素在全身发挥非基因组效应，但它们的很大一部分作用是针对中枢神经系统的。这些作用是由多种信号通路介导的，并导致体外和体内有生理意义的事件。在这里，我们回顾了肾上腺类固醇在中枢神经系统行为、神经系统活动、个体神经元活动和亚细胞信号活动水平上的非基因组效应。更清楚地了解肾上腺类固醇在中枢神经系统中的活性，将有助于更好地治疗人类疾病，并减少已经使用的类固醇治疗的副作用。
Mineralocorticoids and glucocorticoids are steroid hormones that are released by the adrenal cortex in response to stress and hydromineral imbalance. Historically, adrenocorticosteroid actions are attributed to effects on gene transcription. More recently, however, it has become clear that genome-independent pathways represent an important facet of adrenal steroid actions. These hormones exert nongenomic effects throughout the body, but a significant portion of their actions are specific to the central nervous system. These actions are mediated by a variety of signalling pathways, and lead to physiologically meaningful events in vitro and in vivo. Here we review nongenomic effects of adrenal steroids in the central nervous system at the levels of behaviour, neural system activity, individual neurone activity, and subcellular signalling activity. A clearer understanding of adrenal steroid activity in the central nervous system will lead to a better ability both to treat human disease, and to reduce side-effects of steroid treatments already in use.