Short report: Molecular identification of a collection of spotted fever group rickettsiae obtained from patients and ticks from Russia
Short report: Molecular identification of a collection of spotted fever group rickettsiae obtained from patients and ticks from Russia
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DOI：
10.4269/ajtmh.2006.74.440
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发表时间：
2006-03-01
影响因子：
3.3
通讯作者：
Raoult, D
中科院分区：
文献类型：
--
作者：
Shpynov, SN;Fournier, PE;Raoult, D
1954年至2001年期间，在鄂木斯克自然疫源感染研究所从乌拉尔地区至俄罗斯远东地区的北亚蜱斑疹伤寒（NATT）疫源地的蜱或患者中获得了31株立克次体分离株。通过柠檬酸合成酶（gltA）和外膜蛋白A（ompA）基因序列测定，我们将这些分离株鉴定为西伯利亚立克次体狭义立克次体（25株）、R. sibirica菌株BJ-90（2个分离物）、R. slovaca（1个分离物）和R.黑龙江亚种（3个分离物）。我们表明，硬蜱全沟蜱应被视为潜在的载体NATT。我们还证明了R的存在。在乌拉尔和R.在西伯利亚和俄罗斯远东地区，它们可能导致人类感染被误诊为NATT病例。临床医生应该意识到，在俄罗斯，几种不同类型的斑点热立克次体病共存于NATT是以前唯一被承认的立克次体病的地区。
Thirty-one rickettsial isolates from ticks or patients in North Asian tick typhus (NATT) foci from the Ural region to the Russian Far East were obtained at the Omsk Research Institute of Natural Foci Infections between 1954 and 2001. Using citrate synthase (gltA) and outermenbrane protein a (ompA) gene sequencing, we identified these isolates as Rickettsia sibirica sensu stricto (25 isolates), R. sibirica strain BJ-90 (2 isolates), R. slovaca (1 isolate), and R. heilongjiangensis (3 isolates). We demonstrate that Ixodes persulcatus ticks should be considered potential vectors of NATT. We also demonstrate the presence of R. slovaca in Ural and R. heilongjiangensis in Siberia and Russian Far East, where they may cause human infections misdiagnosed as cases of NATT. Clinicians should be aware that several spotted fever rickettsioses with different prognoses coexist in Russia in areas where NATT was the only previously recognized rickettsiosis.