Inhibitory control and affective processing in the prefrontal cortex: Neuropsychological studies in the common marmoset
Inhibitory control and affective processing in the prefrontal cortex: Neuropsychological studies in the common marmoset
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DOI：
10.1093/cercor/10.3.252
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发表时间：
2000-03-01
期刊：
影响因子：
3.7
通讯作者：
Wallis, JD
中科院分区：
文献类型：
--
作者：
Roberts, AC;Wallis, JD
眶额皮质在行为的抑制控制和情绪控制中发挥着重要作用。虽然人类和非人类灵长类动物的眶额皮质受损会导致僵硬、冲动和情绪障碍，但这些影响之间的关系尚不清楚。对狨猴的兴奋性毒性损伤研究比较了前额叶皮层特定区域内细胞损失对一系列行为测试表现的影响，结果表明反应抑制机制并不是眶额皮层所独有的。相反，它们存在于整个前额皮质的低阶和高阶处理的不同认知域中。因此，外侧前额叶皮层参与基于开放高阶规则的动作的选择和控制，而眶额和内侧前额叶皮层可能参与不同但互补形式的低阶规则学习，它们的角色是可分离的，因为它们对不同类型的联想学习的贡献不同。
The orbitofrontal cortex has been ascribed a role in the inhibitory control, as well as in the emotional control, of behaviour. While damage to the orbitofrontal cortex in humans and non-human primates can cause inflexibility, impulsiveness and emotional disturbance, the relationship between these effects are unclear. Excitotoxic lesion studies in marmosets comparing the effects of cell loss within specific regions of the prefrontal cortex on performance of a range of behavioural tests reveal that mechanisms of response inhibition are not unique to the orbitofrontal cortex. Instead they are present in distinct cognitive domains for lower-order as well as higher-order processing throughout the prefrontal cortex. Thus, the lateral prefrontal cortex is involved in the selection and control of action based open higher-order rules while the orbitofrontal and medial prefrontal cortex may be involved in different but complementary forms of lower-order rule learning, their roles dissociable, as a result of their differential contribution to different types of associative learning.