Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
Congestive heart failure in older women treated with adjuvant anthracycline chemotherapy for breast cancer
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DOI：
10.1200/jco.2006.10.4976
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发表时间：
2007-09-01
影响因子：
45.3
通讯作者：
Giordano, Sharon H.
中科院分区：
文献类型：
--
作者：
Pinder, Mary C.;Duan, Zhigang;Giordano, Sharon H.
研究目的：关于65岁以上乳腺癌患者辅助蒽环类化疗的长期心脏安全性的数据有限。我们评估了充血性心力衰竭（CHF）在此population.Patients和MethodsWe使用的监测，流行病学和最终结果医疗数据库，包括妇女没有CHF的历史，年龄在66至80岁，诊断为I期至III期乳腺癌，从1992年至2002年。CHF的累积率进行了估计，多变量考克斯回归分析，以确定与CHF的发展相关的因素。与接受非蒽环类药物或未接受化疗的女性相比，蒽环类药物治疗的女性更年轻，合并症更少，疾病更晚期（P
PurposeLimited data are available on long- term cardiac safety of adjuvant anthracycline chemotherapy in breast cancer patients over age 65 years. We evaluated rates and predictors of congestive heart failure ( CHF) in this population.Patients and MethodsWe used the Surveillance, Epidemiology, and End Results Medicare database and included women with no history of CHF who were age 66 to 80 years and diagnosed with stage I to III breast cancer from 1992 to 2002. Cumulative rates of CHF were estimated, and multivariable Cox regression analysis was used to determine factors associated with the development of CHF.ResultsA total of 43,338 women were included. Anthracycline- treated women were younger, with fewer comorbidities and more advanced disease than women who received nonanthracycline or no chemotherapy ( P