Importance of screening household members of acute brucellosis cases in endemic areas
Importance of screening household members of acute brucellosis cases in endemic areas
复制标题
DOI：
10.1017/s0950268803001857
复制
发表时间：
2004-06-01
影响因子：
4.2
通讯作者：
Alsubaie, S
中科院分区：
文献类型：
--
作者：
Almuneef, MA;Memish, ZA;Alsubaie, S
家庭成员中存在布鲁氏菌病的孤立报告已有记录。本研究的目的是确定对急性布鲁氏菌病病例家庭成员进行主动血清学筛查是否会发现其他未被识别的病例。从2000年5月到2001年10月，招募了急性布氏菌病患者，并使用标准凝集试验（SAT）对其家庭成员进行了布氏菌病血清学筛查。纳入 55 名急性布氏杆菌病指示病例和 404 名家庭成员。大多数指示病例（48%）是年轻人，79% 是文盲。 45% 和 75% 的指示病例分别报告拥有动物和摄入未经高温消毒的生奶。在接受筛查的 55 个家庭中，23 个 (42%) 有两名或以上家庭成员有布鲁氏菌病血清学证据，而 32 个 (58%) 只有指示病例。家庭人口超过或等于 5 人以及家庭成员有生奶摄入史是与血清阳性相关的危险因素 (P < 0(.)05)。在接受筛查的 404 名家庭成员中，53 人（13%）血清呈阳性；其中 39 人（74%）有症状，其中 9 人（35%）患有布鲁氏菌菌血症。与无症状血清阳性者相比，有症状的血清阳性者往往有菌血症和较高的布鲁氏菌抗体滴度（P 小于或等于 0(.)05）。对急性布鲁氏菌病指示病例的家庭成员进行筛查将发现更多病例。
Isolated reports of brucellosis among family members have been documented. The aim of this study is to determine if active serological screening of the households' members of acute brucellosis cases will detect additional unrecognized cases. From May 2000 to October 2001, patients with acute brucellosis were enrolled and their household members were serologically screened for brucellosis using the Standard Agglutination Test (SAT). Fifty-five index cases with acute brucellosis and 404 household members were enrolled. The majority of index cases (48%) were young adults, and 79% were illiterate. Ownership of animals and ingestion of unpasteurized raw milk were reported by 45 and 75% of the index cases respectively. Of the 55 families screened, 23 (42%) had two family members or more with serological evidence of brucellosis and 32 (58%) had only the index case. Households of greater than or equal to 5 members and a history of raw-milk ingestion by family members were risk factors associated with the seropositives (P < 0(.)05). Of the 404 household members screened, 53 (13%) were seropositive; of these 39 (74%) were symptomatic, and 9 (35%) had brucella bacteraemia. Symptomatic seropositives tended to have bacteraemia and higher brucella antibody titres compared to asymptomatic seropositives (P less than or equal to 0(.)05). Screening family members of an index case of acute brucellosis will detect additional cases.